TAS2R43

味觉感受器，类型2，成员43
味觉感受器，类型2，成员43
标识
代号	TAS2R43; T2R43; T2R52
扩展标识	遗传学：612668 同源基因：128798 IUPHAR: GeneCards: TAS2R43 Gene
基因本体论描述
分子功能	· taste receptor activity; · bitter taste receptor activity;
细胞成分	· integral to membrane; · motile cilium; · cilium membrane;
生物过程	· detection of chemical stimulus involved in sensory perception of bitter taste; · G-protein coupled receptor signaling pathway;
	Sources: Amigo / QuickGO
直系同源体
物种	人类
Entrez	259289
Ensembl	ENSG00000255374
UniProt	P59537
mRNA序列	NM_176884
蛋白序列	NP_795365
基因位置	Chr 12:; 11.24 – 11.24 Mb
PubMed查询	[1]
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味觉感受器，类型2，成员43，TAS2R43 是一个人类基因组中TAS2R43基因编码的蛋白质，是苦味味觉感受器的一员。^[1]^[2]

Quick Facts 味觉感受器，类型2，成员43, 标识 ...

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味觉感受器

参考文献

[1]
Bufe B, Hofmann T, Krautwurst D, Raguse JD, Meyerhof W. The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides. Nat Genet. Oct 2002, 32 (3): 397–401. PMID 12379855. doi:10.1038/ng1014.
[2]
Entrez Gene: TAS2R43 taste receptor, type 2, member 43.

延伸阅读

Margolskee RF. Molecular mechanisms of bitter and sweet taste transduction.. J. Biol. Chem. 2002, 277 (1): 1–4. PMID 11696554. doi:10.1074/jbc.R100054200.
Montmayeur JP, Matsunami H. Receptors for bitter and sweet taste.. Curr. Opin. Neurobiol. 2002, 12 (4): 366–71. PMID 12139982. doi:10.1016/S0959-4388(02)00345-8.
Strausberg RL, Feingold EA, Grouse LH; et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Zhang Y, Hoon MA, Chandrashekar J; et al. Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.. Cell. 2003, 112 (3): 293–301. PMID 12581520. doi:10.1016/S0092-8674(03)00071-0.
Conte C, Ebeling M, Marcuz A; et al. Identification and characterization of human taste receptor genes belonging to the TAS2R family.. Cytogenet. Genome Res. 2003, 98 (1): 45–53. PMID 12584440. doi:10.1159/000068546.
Gerhard DS, Wagner L, Feingold EA; et al. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 2004, 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Fischer A, Gilad Y, Man O, Pääbo S. Evolution of bitter taste receptors in humans and apes.. Mol. Biol. Evol. 2005, 22 (3): 432–6. PMID 15496549. doi:10.1093/molbev/msi027.
Kuhn C, Bufe B, Winnig M; et al. Bitter taste receptors for saccharin and acesulfame K.. J. Neurosci. 2005, 24 (45): 10260–5. PMID 15537898. doi:10.1523/JNEUROSCI.1225-04.2004.
Go Y, Satta Y, Takenaka O, Takahata N. Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates.. Genetics. 2006, 170 (1): 313–26. PMC 1449719 . PMID 15744053. doi:10.1534/genetics.104.037523.
Behrens M, Bartelt J, Reichling C; et al. Members of RTP and REEP gene families influence functional bitter taste receptor expression.. J. Biol. Chem. 2006, 281 (29): 20650–9. PMID 16720576. doi:10.1074/jbc.M513637200.

[pmid12379855-1] [1]
Bufe B, Hofmann T, Krautwurst D, Raguse JD, Meyerhof W. The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides. Nat Genet. Oct 2002, 32 (3): 397–401. PMID 12379855. doi:10.1038/ng1014.

[entrez-2] [2]
Entrez Gene: TAS2R43 taste receptor, type 2, member 43.

[1]

[2]