酰基辅酶A硫酯酶7

酰基辅酶A硫酯酶7（英语：Acyl-CoA thioesterase 7）是一种在人类中由ACOT7基因编码的酶。^[5][6][7][8]

酰基辅酶A硫酯酶7
已知的结构 PDB 直系同源搜索: PDBe RCSB PDBID列表 2QQ2
识别号
别名	ACOT7；, ACH1, ACT, BACH, CTE-II, LACH, LACH1, hBACH, acyl-CoA thioesterase 7
外部ID	OMIM：602587 MGI：1917275 HomoloGene：15780 GeneCards：ACOT7
基因位置（人类） 染色体 1号染色体[1] 基因座 1p36.31 起始 6,264,269 bp[1] 终止 6,393,767 bp[1]
基因位置（小鼠） 染色体 小鼠4号染色体[2] 基因座 4|4 E2 起始 152,262,591 bp[2] 终止 152,356,312 bp[2]
RNA表达模式
查阅更多表达数据
基因本体 分子功能 • palmitoyl-CoA hydrolase activity • fatty-acyl-CoA binding • protein homodimerization activity • carboxylic ester hydrolase activity • long-chain fatty acyl-CoA binding • 血浆蛋白结合 • 水解酶活性 • acyl-CoA hydrolase activity • myristoyl-CoA hydrolase activity • thiolester hydrolase activity 细胞组分 • 细胞质基质 • 核质 • 线粒体 • 外排体 • 细胞质 生物学过程 • medium-chain fatty acid biosynthetic process • medium-chain fatty-acyl-CoA catabolic process • long-chain fatty-acyl-CoA catabolic process • coenzyme A biosynthetic process • palmitic acid biosynthetic process • acyl-CoA metabolic process • 脂质代谢 • 脂肪酸代谢 Sources:Amigo / QuickGO
直系同源
物种	人类	小鼠
Entrez	11332	70025
Ensembl	ENSG00000097021	ENSMUSG00000028937
UniProt	O00154	Q91V12
mRNA​序列	NM_181866 ​NM_007274 ​NM_181862 ​NM_181863 ​NM_181864 ​NM_181865	NM_001146057 ​NM_001146058 ​NM_133348 ​NM_001369273 ​NM_001369274 ​NM_001369275 ​NM_001369276
蛋白序列	NP_009205 ​NP_863654 ​NP_863655 ​NP_863656	NP_001139529 ​NP_001139530 ​NP_579926 ​NP_001356202 ​NP_001356203 ​NP_001356204 ​NP_001356205
基因位置​（UCSC）	Chr 1: 6.26 – 6.39 Mb	Chr 4: 152.26 – 152.36 Mb
PubMed​查找	[3]	[4]
维基数据
查看/编辑人类 查看/编辑小鼠

该基因编码酰基辅酶家族的一个成员。编码的蛋白质水解棕榈酰辅酶A的辅酶A硫酯和其他长链脂肪酸。该基因表达的减少可能与内侧颞叶癫痫有关。编码具有不同亚细胞位置的不同异构体的选择性剪接转录变体已经被表征。^[8]

参考资料

1. GRCh38: Ensembl release 89: ENSG00000097021 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028937 - Ensembl, May 2017
3. Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Yamada J, Kurata A, Hirata M, Taniguchi T, Takama H, Furihata T, Shiratori K, Iida N, Takagi-Sakuma M, Watanabe T, Kurosaki K, Endo T, Suga T. Purification, molecular cloning, and genomic organization of human brain long-chain acyl-CoA hydrolase. J Biochem. Mar 2000, 126 (6): 1013–9. PMID 10578051. doi:10.1093/oxfordjournals.jbchem.a022544.
6. Hunt MC, Yamada J, Maltais LJ, Wright MW, Podesta EJ, Alexson SE. A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases. J Lipid Res. Aug 2005, 46 (9): 2029–32. PMID 16103133. doi:10.1194/jlr.E500003-JLR200 .
7. Hunt MC, Rautanen A, Westin MA, Svensson LT, Alexson SE. Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs. FASEB J. Aug 2006, 20 (11): 1855–64 [2023-03-07]. PMID 16940157. S2CID 501610. doi:10.1096/fj.06-6042com. （原始内容存档于2017-11-03）.
8. Entrez Gene: ACOT7 acyl-CoA thioesterase 7.

外部链接

• Human ACOT7 genome location and ACOT7 gene details page in the UCSC Genome Browser（英语：UCSC Genome Browser）.

延申阅读

• Yamada J. Long-chain acyl-CoA hydrolase in the brain.. Amino Acids. 2006, 28 (3): 273–8. PMID 15731883. S2CID 10678899. doi:10.1007/s00726-005-0181-1.
• Yamada J, Kuramochi Y, Takagi M, et al. Human brain acyl-CoA hydrolase isoforms encoded by a single gene.. Biochem. Biophys. Res. Commun. 2003, 299 (1): 49–56. PMID 12435388. doi:10.1016/S0006-291X(02)02587-1.
• Strausberg RL, Feingold EA, Grouse LH, et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. 2003, 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899 .
• Ota T, Suzuki Y, Nishikawa T, et al. Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. 2004, 36 (1): 40–5. PMID 14702039. doi:10.1038/ng1285 .
• Gerhard DS, Wagner L, Feingold EA, et al. The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC). Genome Res. 2004, 14 (10B): 2121–7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
• Yang JW, Czech T, Yamada J, et al. Aberrant cytosolic acyl-CoA thioester hydrolase in hippocampus of patients with mesial temporal lobe epilepsy. Amino Acids. 2005, 27 (3–4): 269–75. PMID 15592755. S2CID 2832201. doi:10.1007/s00726-004-0138-9.
• Gregory SG, Barlow KF, McLay KE, et al. The DNA sequence and biological annotation of human chromosome 1. Nature. 2006, 441 (7091): 315–21. Bibcode:2006Natur.441..315G. PMID 16710414. doi:10.1038/nature04727 .
• Lim J, Hao T, Shaw C, et al. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. Cell. 2006, 125 (4): 801–14. PMID 16713569. S2CID 13709685. doi:10.1016/j.cell.2006.03.032 .