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肝内的胆小管逐级合并成左、右肝管，出肝门再合成为肝总管；肝总管与胆囊管汇合成胆总管。
肝细胞持续不断的制造胆汁浓缩并储存于胆囊中；平时胆汁由肝管、肝总管经过胆囊管入胆囊，进食时贮存于胆囊的浓缩胆汁经过胆囊管、胆总管进入十二指肠。
当脂肪进入十二指肠中会刺激胆囊间歇的分泌出胆汁帮助分解脂肪。
胆囊管发生梗塞可引起胆囊积液，而肝总管或胆总管发生梗塞则造成阻塞性黄疸。
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