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吡莫地韦
维基百科,自由的 encyclopedia
吡莫地韦(VX-787,JNJ-63623872)是一种抗病毒药,被开发用于治疗流感。它可作为流感病毒聚合酶碱性蛋白2的抑制剂,并在II期临床试验中显示出较好的疗效。[1][2][3]
参考文献
- Trevejo JM, Asmal M, Vingerhoets J, Polo R, Robertson S, Jiang Y, Kieffer TL, Leopold L. Pimodivir treatment in adult volunteers experimentally inoculated with live influenza virus: a Phase IIa, randomized, double-blind, placebo-controlled study. Antivir Ther. 2018;23(4):335-344. PMID 29244026doi:10.3851/IMP3212
- Finberg RW, Lanno R, Anderson D, Fleischhackl R, van Duijnhoven W, Kauffman RS, Kosoglou T, Vingerhoets J, Leopold L. Phase 2b Study of Pimodivir (JNJ-63623872) as Monotherapy or in Combination With Oseltamivir for Treatment of Acute Uncomplicated Seasonal Influenza A: TOPAZ Trial. J Infect Dis. 2019 Mar 15;219(7):1026-1034. PMID 30428049doi:10.1093/infdis/jiy547
- Beigel JH, Nam HH, Adams PL, Krafft A, Ince WL, El-Kamary SS, Sims AC. Advances in respiratory virus therapeutics - A meeting report from the 6th isirv Antiviral Group conference. Antiviral Res. 2019 Jul;167:45-67. PMID 30974127 doi:10.1016/j.antiviral.2019.04.006
参见
- 巴洛沙韦马波地尔(英语:Baloxavir marboxil)
- 法维皮拉韦(英语:Favipiravir) (T-705; Avigan)
- 三氮唑林(英语:Triazavirin) (TZV)
- 阿比朵尔
Quick Facts 临床资料, 商品名(英语:Drug nomenclature) ...
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临床资料 | |
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商品名(英语:Drug nomenclature) | Pimodivir |
法律规范状态 | |
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CAS号 | 1629869-44-8 |
PubChem CID | |
化学信息 | |
化学式 | C20H19F2N5O2 |
摩尔质量 | 399.4 |
3D模型(JSmol(英语:JSmol)) | |
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