胱天蛋白酶10

胱天蛋白酶10（英语：Caspase 10）是一种在人类中由CASP10基因编码的酶。^[5]

胱天蛋白酶10
识别号
别名	CASP10；, ALPS2, FLICE2, MCH4, Caspase 10, FLICE-2
外部ID	OMIM：601762 HomoloGene：50038 GeneCards：CASP10
相关疾病
autoimmune lymphoproliferative syndrome type 2A、​非霍奇金氏淋巴瘤[1]
为以下药物的标靶
emricasan[2]
基因位置（人类） 染色体 2号染色体[3] 基因座 2q33.1 起始 201,182,872 bp[3] 终止 201,229,428 bp[3]
RNA表达模式
查阅更多表达数据
基因本体 分子功能 • death effector domain binding • 肽酶活性 • 半胱氨酸型肽酶活性 • 血浆蛋白结合 • 水解酶活性 • 泛素蛋白连接酶结合 • cysteine-type endopeptidase activity involved in execution phase of apoptosis • cysteine-type endopeptidase activity • cysteine-type endopeptidase activity involved in apoptotic signaling pathway • cysteine-type endopeptidase activity involved in apoptotic process 细胞组分 • ripoptosome • 细胞质基质 • CD95 death-inducing signaling complex • 细胞质 生物学过程 • positive regulation of I-kappaB kinase/NF-kappaB signaling • apoptotic signaling pathway • cell surface receptor signaling pathway • 蛋白酶解 • 细胞凋亡 • regulation of apoptotic process • execution phase of apoptosis • activation of cysteine-type endopeptidase activity involved in apoptotic process Sources:Amigo / QuickGO
直系同源
物种	人类	小鼠
Entrez	843	无数据
Ensembl	ENSG00000003400	无数据
UniProt	Q92851	无数据
mRNA​序列	​NM_001206524 ​NM_001206542 ​NM_001230 ​NM_001306083 ​NM_032974 ​NM_032976 ​NM_032977	无数据
蛋白序列	NP_001193453 ​NP_001193471 ​NP_001221 ​NP_001293012 ​NP_116756 ​NP_116758 ​NP_116759	无数据
基因位置​（UCSC）	Chr 2: 201.18 – 201.23 Mb	无数据
PubMed​查找	[4]	无数据
维基数据
查看/编辑人类

该基因编码的蛋白质是胱天蛋白酶家族的成员。胱天蛋白酶的连续激活在细胞凋亡的执行阶段发挥着核心作用。胱天蛋白酶以无活性的酶原形式存在，在保守的天冬氨酸残基处经历蛋白水解加工，产生一大一小两个亚基，然后二聚化形成活性酶。

胱天蛋白酶9裂解并激活胱天蛋白酶3和7，而该酶本身由胱天蛋白酶8加工。该基因的突变与II型自身免疫性淋巴细胞增生综合征中出现的细胞凋亡缺陷相关。该基因有三种编码不同异构体的选择性剪接的转录变体。^[6]

相互作用

胱天蛋白酶10已被证明可以与以下物质相互作用：

• FADD^[7][8][9]
• CFLAR^[8][10][11]
• 胱天蛋白酶8^[12][13][14]
• Fas受体^[12][7][15]
• RYBP^[16]
• TNFRSF1A^[12][7]
• TNFRSF10B^[12][15]

参见

• 蛋白酶解图谱（英语：The Proteolysis Map）

参考文献

1. 與胱天蛋白酶10相關的疾病；在維基數據上查看/編輯參考.
2. 對Caspase 10起作用的藥物；在維基數據上查看/編輯參考.
3. GRCh38: Ensembl release 89: ENSG00000003400 - Ensembl, May 2017
4. Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Fernandes-Alnemri T, Armstrong RC, Krebs J, Srinivasula SM, Wang L, Bullrich F, Fritz LC, Trapani JA, Tomaselli KJ, Litwack G, Alnemri ES. In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains. Proc Natl Acad Sci USA. October 1996, 93 (15): 7464–9. Bibcode:1996PNAS...93.7464F. PMC 38767 . PMID 8755496. doi:10.1073/pnas.93.15.7464 .
6. Entrez Gene: CASP10 caspase 10, apoptosis-related cysteine peptidase.
7. Vincenz, C; Dixit V M. Fas-associated death domain protein interleukin-1beta-converting enzyme 2 (FLICE2), an ICE/Ced-3 homologue, is proximally involved in CD95- and p55-mediated death signaling. J. Biol. Chem. (UNITED STATES). March 1997, 272 (10): 6578–83. ISSN 0021-9258. PMID 9045686. doi:10.1074/jbc.272.10.6578 .
8. Srinivasula SM, Ahmad M, Ottilie S, Bullrich F, Banks S, Wang Y, Fernandes-Alnemri T, Croce CM, Litwack G, Tomaselli KJ, Armstrong RC, Alnemri ES. FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis. J. Biol. Chem. (UNITED STATES). July 1997, 272 (30): 18542–5. ISSN 0021-9258. PMID 9228018. doi:10.1074/jbc.272.30.18542 .
9. Wang, J; Chun H J; Wong W; Spencer D M; Lenardo M J. Caspase-10 is an initiator caspase in death receptor signaling. Proc. Natl. Acad. Sci. U.S.A. (United States). November 2001, 98 (24): 13884–8. Bibcode:2001PNAS...9813884W. ISSN 0027-8424. PMC 61136 . PMID 11717445. doi:10.1073/pnas.241358198 .
10. Micheau, Olivier; Tschopp Jürg. Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell (United States). July 2003, 114 (2): 181–90. ISSN 0092-8674. PMID 12887920. doi:10.1016/S0092-8674(03)00521-X .
11. Goltsev, Y V; Kovalenko A V; Arnold E; Varfolomeev E E; Brodianskii V M; Wallach D. CASH, a novel caspase homologue with death effector domains. J. Biol. Chem. (UNITED STATES). August 1997, 272 (32): 19641–4. ISSN 0021-9258. PMID 9289491. doi:10.1074/jbc.272.32.19641 .
12. Gajate, Consuelo; Mollinedo Faustino. Cytoskeleton-mediated death receptor and ligand concentration in lipid rafts forms apoptosis-promoting clusters in cancer chemotherapy. J. Biol. Chem. (United States). March 2005, 280 (12): 11641–7. ISSN 0021-9258. PMID 15659383. doi:10.1074/jbc.M411781200 .
13. Guo, Yin; Srinivasula Srinivasa M; Druilhe Anne; Fernandes-Alnemri Teresa; Alnemri Emad S. Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria. J. Biol. Chem. (United States). April 2002, 277 (16): 13430–7. ISSN 0021-9258. PMID 11832478. doi:10.1074/jbc.M108029200 .
14. Srinivasula, S M; Ahmad M; Fernandes-Alnemri T; Litwack G; Alnemri E S. Molecular ordering of the Fas-apoptotic pathway: The Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases. Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES). December 1996, 93 (25): 14486–91. Bibcode:1996PNAS...9314486S. ISSN 0027-8424. PMC 26159 . PMID 8962078. doi:10.1073/pnas.93.25.14486 .
15. MacFarlane, M; Ahmad M; Srinivasula S M; Fernandes-Alnemri T; Cohen G M; Alnemri E S. Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL. J. Biol. Chem. (UNITED STATES). October 1997, 272 (41): 25417–20. ISSN 0021-9258. PMID 9325248. doi:10.1074/jbc.272.41.25417 .
16. Zheng, L; Schickling O; Peter M E; Lenardo M J. The death effector domain-associated factor plays distinct regulatory roles in the nucleus and cytoplasm. J. Biol. Chem. (United States). August 2001, 276 (34): 31945–52. ISSN 0021-9258. PMID 11395500. doi:10.1074/jbc.M102799200 .

拓展阅读

• Cohen GM. Caspases: the executioners of apoptosis. Biochem. J. 1997, 326 (Pt 1): 1–16. PMC 1218630 . PMID 9337844. doi:10.1042/bj3260001.
• Clements GB, Klein G, Povey S. Production by EBV infection of an EBNA-positive subline from an EBNA-negative human lymphoma cell line without detectable EBV DNA. Int. J. Cancer. 1975, 16 (1): 125–33. PMID 170210. S2CID 30408863. doi:10.1002/ijc.2910160114.
• Baumann K, de Rouffignac C, Roinel N, et al. Renal phosphate transport: inhomogeneity of local proximal transport rates and sodium dependence. Pflügers Arch. 1975, 356 (4): 287–98. PMID 1171445. S2CID 259484. doi:10.1007/BF00580003.
• DuBridge RB, Tang P, Hsia HC, et al. Analysis of mutation in human cells by using an Epstein-Barr virus shuttle system. Mol. Cell. Biol. 1987, 7 (1): 379–87. PMC 365079 . PMID 3031469. doi:10.1128/mcb.7.1.379.
• Maruyama K, Sugano S. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. Gene. 1994, 138 (1–2): 171–4. PMID 8125298. doi:10.1016/0378-1119(94)90802-8.
• Fernandes-Alnemri T, Takahashi A, Armstrong R, et al. Mch3, a novel human apoptotic cysteine protease highly related to CPP32. Cancer Res. 1996, 55 (24): 6045–52. PMID 8521391.
• Srinivasula SM, Ahmad M, Fernandes-Alnemri T, et al. Molecular ordering of the Fas-apoptotic pathway: The Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases. Proc. Natl. Acad. Sci. U.S.A. 1997, 93 (25): 14486–91. Bibcode:1996PNAS...9314486S. PMC 26159 . PMID 8962078. doi:10.1073/pnas.93.25.14486 .
• Vincenz C, Dixit VM. Fas-associated death domain protein interleukin-1beta-converting enzyme 2 (FLICE2), an ICE/Ced-3 homologue, is proximally involved in CD95- and p55-mediated death signaling. J. Biol. Chem. 1997, 272 (10): 6578–83. PMID 9045686. doi:10.1074/jbc.272.10.6578 .
• Bourquin JP, Stagljar I, Meier P, et al. A serine/arginine-rich nuclear matrix cyclophilin interacts with the C-terminal domain of RNA polymerase II. Nucleic Acids Res. 1997, 25 (11): 2055–61. PMC 146702 . PMID 9153302. doi:10.1093/nar/25.11.2055.
• Shu HB, Halpin DR, Goeddel DV. Casper is a FADD- and caspase-related inducer of apoptosis. Immunity. 1997, 6 (6): 751–63. PMID 9208847. doi:10.1016/S1074-7613(00)80450-1 .
• Srinivasula SM, Ahmad M, Ottilie S, et al. FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis. J. Biol. Chem. 1997, 272 (30): 18542–5. PMID 9228018. doi:10.1074/jbc.272.30.18542 .
• Goltsev YV, Kovalenko AV, Arnold E, et al. CASH, a novel caspase homologue with death effector domains. J. Biol. Chem. 1997, 272 (32): 19641–4. PMID 9289491. doi:10.1074/jbc.272.32.19641 .
• MacFarlane M, Ahmad M, Srinivasula SM, et al. Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL. J. Biol. Chem. 1997, 272 (41): 25417–20. PMID 9325248. doi:10.1074/jbc.272.41.25417 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. Gene. 1997, 200 (1–2): 149–56. PMID 9373149. doi:10.1016/S0378-1119(97)00411-3.
• Hu S, Snipas SJ, Vincenz C, et al. Caspase-14 is a novel developmentally regulated protease. J. Biol. Chem. 1998, 273 (45): 29648–53. PMID 9792675. doi:10.1074/jbc.273.45.29648 .
• Ng PW, Porter AG, Jänicke RU. Molecular cloning and characterization of two novel pro-apoptotic isoforms of caspase-10. J. Biol. Chem. 1999, 274 (15): 10301–8. PMID 10187817. doi:10.1074/jbc.274.15.10301 .
• Wang J, Zheng L, Lobito A, et al. Inherited human Caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II. Cell. 1999, 98 (1): 47–58. PMID 10412980. doi:10.1016/S0092-8674(00)80605-4 .
• Satoh S, Hijikata M, Handa H, Shimotohno K. Caspase-mediated cleavage of eukaryotic translation initiation factor subunit 2alpha. Biochem. J. 1999, 342 (Pt 1): 65–70. PMC 1220437 . PMID 10432301. doi:10.1042/0264-6021:3420065.

外部链接

• GeneReviews/NCBI/NIH/UW 有关自身免疫性淋巴增殖综合征的条目 （页面存档备份，存于互联网档案馆）
• 肽酶及其抑制剂的MEROPS在线数据库：C14.011^{[失效链接]}