硫酸-4-乙基苯酯

硫酸-4-乙基苯酯是一种单硫酸酯，化学式为C₈H₁₀O₄S。它可由4-乙基苯酚和三甲胺三氧化硫或氯磺酸反应制得。^[1][2]

硫酸-4-乙基苯酯
别名	O-(4-乙基苯基)硫酸
识别
CAS号	85734-98-1  Y
PubChem	20822574
性质
化学式	C8H10O4S
摩尔质量	202.23 g·mol−1
若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

它是肠道细菌产生的代谢物，大量存在时有毒。这种代谢物水平升高与一些疾病有关，包括慢性肾病和自闭症。^{[3][4][5][6][7]}

参考文献

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2. Grimes, A. J. Synthesis of S35-labeled arylsulfates by intact animals and by tissue preparations, with particular reference to L-tyrosine O-sulfate. Biochemical Journal, 1959. 73: 732-739. ISSN 0264-6021.
3. Itoh Y, Ezawa A, Kikuchi K, Tsuruta Y, Niwa T. Correlation between Serum Levels of Protein-Bound Uremic Toxins in Hemodialysis Patients Measured by LC/MS/MS. Mass Spectrometry: S0017. PMID 24349936. doi:10.5702/massspectrometry.S0017.
4. Ilievski V, Kinchen JM, Prabhu R, Rim F, Leoni L, Unterman TG, Watanabe K. Experimental Periodontitis Results in Prediabetes and Metabolic Alterations in Brain, Liver and Heart: Global Untargeted Metabolomic Analyses. Journal of Oral Biology. PMID 27390783. doi:10.13188/2377-987X.1000020.
5. Virdee MS, Saini N, Kay CD, Neilson AP, Kwan ST, Helfrich KK, et al. An enriched biosignature of gut microbiota-dependent metabolites characterizes maternal plasma in a mouse model of fetal alcohol spectrum disorder. Scientific Reports. January 2021, 11 (1): 248. PMID 33420159. doi:10.1038/s41598-020-80093-8.
6. Zheng Y, Bek MK, Prince NZ, Peralta Marzal LN, Garssen J, Perez Pardo P, Kraneveld AD. The Role of Bacterial-Derived Aromatic Amino Acids Metabolites Relevant in Autism Spectrum Disorders: A Comprehensive Review. Frontiers in Neuroscience: 738220. PMID 34744609. doi:10.3389/fnins.2021.738220.
7. Needham BD, Funabashi M, Adame MD, Wang Z, Boktor JC, Haney J, et al. A gut-derived metabolite alters brain activity and anxiety behaviour in mice. Nature. February 2022, 602 (7898): 647–653. PMID 35165440. doi:10.1038/s41586-022-04396-8.