甘草次酸

甘草次酸
临床资料
商品名（英语：Drug nomenclature）	Arthrodont, PruClair
AHFS/Drugs.com	国际药品名称
给药途径	Oral, topical
ATC码	D03AX10 (WHO) ;
法律规范状态
法律规范	美：处方药（℞-only）;
识别信息
	IUPAC命名法 (2S,4aS,6aS,6bR,8aR,10S,12aS,12bR,14bR)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid; OR; (1R,2R,5S,8S,10R,14R,15S,18S,20R)-18-hydroxy-1,2,5,8,15,19,19-heptamethyl-13-oxopentacyclo[12.8.0.02,11.05,10.015,20]docos-11-ene-8-carboxylic acid; ;
CAS号	471-53-4
PubChem CID	10114;
ChemSpider	9710;
ChEBI	CHEBI:30853;
ChEMBL	ChEMBL230006;
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID9020669 ;
ECHA InfoCard	100.006.769
化学信息
化学式	C30H46O4
摩尔质量	470.6838
3D模型（JSmol（英语：JSmol））	交互式图像;
	SMILES O=C(O)[C@]5(C)C[C@H]4/C3=C/C(=O)[C@H]1[C@](CC[C@@H]2[C@]1(C)CC[C@H](O)C2(C)C)(C)[C@]3(C)CC[C@@]4(C)CC5;
	InChI InChI=1S/C30H46O4/c1-25(2)21-8-11-30(7)23(28(21,5)10-9-22(25)32)20(31)16-18-19-17-27(4,24(33)34)13-12-26(19,3)14-15-29(18,30)6/h16,19,21-23,32H,8-15,17H2,1-7H3,(H,33,34)/t19-,21-,22-,23+,26+,27-,28-,29+,30+/m0/s1; Key:MPDGHEJMBKOTSU-YKLVYJNSSA-N;

甘草次酸（glycyrrhetinic acid，或glycyrrhetic acid，也叫Enoxolone）是一种五环三萜物质，由草药光果甘草的甘草酸水解得到故而得名。甘草次酸可以看作是β-香树脂醇（齐墩果烷型）的衍生物，从而作为甘草酸的糖苷配基。甘草次酸常作为香料使用，也用来掩盖芦荟和奎宁等药物的苦味。^[1]^[2]^[3]^[4]^[5]

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[1]
Chandler, RF. Liquorice, more than just a flavour. Canadian Pharmaceutical Journal. 1985, (118): 420–4.
[2]
Badam, L.; Amagaya, S.; Pollard, B. In vitro activity of licorice and glycyrrhetinic acid on Japanese encephalitis virus.. J. Community Dis. 1997, 29: 91–99.
[3]
Fuji, H.Y.; Tian, J.; Luka, C. Effect of glycyrrhetinic acid on influenza virus and pathogenic bacteria.. Bull. Chin. Mater. Med. 1986, 11: 238–241.
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Guo, N.; Takechi, M.; Uno, C. Protective effect of glycyrrhizine in mice with systemic Candida albicans infection and its mechanism. J. Pharm. Pharmacol. 1991, 13 (5): 380–383. PMID 1839259.
[5]
Salari, M. H.; Sohrabi, N.; Kadkhoda, Z.; and Khalili, M. B.; capnophilic bacteria isolated from specimens of periodontitis patients. Antibacterial effects of Enoxolone on periodontopathogenic. Iran. Biomed. J. 2003, 7: 39–42.

Saponin Glycosides （页面存档备份，存于互联网档案馆）, by Georges-Louis Friedli, URL accessed Sept 2010.

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