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中轴骨(英语:axial skeleton),也称主轴骨、中轴骨骼、主轴骨骼,是指脊椎动物包含头和躯干在内的骨骼结构。中轴骨是骨骼系统的一部分。人类骨架结构中,中轴骨由80块骨头组成,被分成六大主要组成部分:颅骨、中耳的听小骨、舌骨、肋骨、胸骨和脊椎。中轴骨和附肢骨骼一起构成了一套完整的骨骼系统。[1]
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