SS18

SSXT蛋白，是一类蛋白。在人体是由SS18基因编码^[1][2][3]。

Synovial sarcoma translocation, chromosome 18 第18染色体，滑液肉瘤易位
标识
代号	SS18; SSXT; SYT
扩展标识	遗传学：600192 鼠基因：107708 同源基因：38080 GeneCards: SS18 Gene
基因本体论描述 分子功能 · protein binding · ligand-dependent nuclear receptor transcription coactivator activity 细胞成分 · nucleus · cytoplasmic microtubule · npBAF complex 生物过程 · microtubule cytoskeleton organization · cell morphogenesis · transcription, DNA-templated · intracellular signal transduction · response to drug · positive regulation of transcription from RNA polymerase II promoter · ephrin receptor signaling pathway · neuronal stem cell maintenance Sources: Amigo / QuickGO
RNA表达模式
更多表达数据
直系同源体
物种	人类	小鼠
Entrez	6760	268996
Ensembl	ENSG00000141380	ENSMUSG00000037013
UniProt	Q15532	Q62280
mRNA序列	NM_001007559	NM_001161369
蛋白序列	NP_001007560	NP_001154841
基因位置	Chr 18: 26.02 – 26.09 Mb	Chr 18: 14.62 – 14.68 Mb
PubMed查询	[1]	[2]
查 论 编

结构

SS18是一种人类SWI/SNF染色质重塑复合物^[4][5][6]。

临床意义

SS18参与到染色体易位中，并常见于滑膜肉瘤^[7]。

交互作用

SS18与以下蛋白质产生相互作用：

• EP300（英语：EP300）^[8]
• MLLT10（英语：MLLT10）^[9]
• SMARCA2（英语：SMARCA2）^[6]
• SMARCB1（英语：SMARCB1）^[5]

参考

1. Shipley JM, Clark J, Crew AJ, Birdsall S, Rocques PJ, Gill S, Chelly J, Monaco AP, Abe S, Gusterson BA. The t(X;18)(p11.2;q11.2) translocation found in human synovial sarcomas involves two distinct loci on the X chromosome. Oncogene. May 1994, 9 (5): 1447–53. PMID 8152806.
2. Clark J, Rocques PJ, Crew AJ, Gill S, Shipley J, Chan AM, Gusterson BA, Cooper CS. Identification of novel genes, SYT and SSX, involved in the t(X;18)(p11.2;q11.2) translocation found in human synovial sarcoma. Nature Genetics. Aug 1994, 7 (4): 502–8. PMID 7951320. doi:10.1038/ng0894-502.
3. de Bruijn DR, Geurts van Kessel A. Common origin of the human synovial sarcoma associated SS18 and SS18L1 gene loci. Cytogenetic and Genome Research. 2006, 112 (3-4): 222–6. PMID 16484776. doi:10.1159/000089874.
4. Middeljans E, Wan X, Jansen PW, Sharma V, Stunnenberg HG, Logie C. SS18 together with animal-specific factors defines human BAF-type SWI/SNF complexes. PLOS ONE. 2012, 7 (3): e33834. PMC 3307773 . PMID 22442726. doi:10.1371/journal.pone.0033834.
5. Kato H, Tjernberg A, Zhang W, Krutchinsky AN, An W, Takeuchi T, Ohtsuki Y, Sugano S, de Bruijn DR, Chait BT, Roeder RG. SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones. The Journal of Biological Chemistry. Feb 2002, 277 (7): 5498–505. PMID 11734557. doi:10.1074/jbc.M108702200.
6. Perani M, Ingram CJ, Cooper CS, Garrett MD, Goodwin GH. Conserved SNH domain of the proto-oncoprotein SYT interacts with components of the human chromatin remodelling complexes, while the QPGY repeat domain forms homo-oligomers. Oncogene. Nov 2003, 22 (50): 8156–67. PMID 14603256. doi:10.1038/sj.onc.1207031.
7. Yang K, Lui WO, Xie Y, Zhang A, Skytting B, Mandahl N, Larsson C, Larsson O. Co-existence of SYT-SSX1 and SYT-SSX2 fusions in synovial sarcomas. Oncogene. Jun 2002, 21 (26): 4181–90. PMID 12037676. doi:10.1038/sj.onc.1205569.
8. Eid JE, Kung AL, Scully R, Livingston DM. p300 interacts with the nuclear proto-oncoprotein SYT as part of the active control of cell adhesion. Cell. Sep 2000, 102 (6): 839–48. PMID 11030627. doi:10.1016/S0092-8674(00)00072-6.
9. de Bruijn DR, dos Santos NR, Thijssen J, Balemans M, Debernardi S, Linder B, Young BD, Geurts van Kessel A. The synovial sarcoma associated protein SYT interacts with the acute leukemia associated protein AF10. Oncogene. May 2001, 20 (25): 3281–9. PMID 11423977. doi:10.1038/sj.onc.1204419.

延伸阅读

• Fligman I, Lonardo F, Jhanwar SC, Gerald WL, Woodruff J, Ladanyi M. Molecular diagnosis of synovial sarcoma and characterization of a variant SYT-SSX2 fusion transcript. The American Journal of Pathology. Dec 1995, 147 (6): 1592–9. PMC 1869933 . PMID 7495284.
• Brett D, Whitehouse S, Antonson P, Shipley J, Cooper C, Goodwin G. The SYT protein involved in the t(X;18) synovial sarcoma translocation is a transcriptional activator localised in nuclear bodies. Human Molecular Genetics. Sep 1997, 6 (9): 1559–64. PMID 9285794. doi:10.1093/hmg/6.9.1559.
• Thaete C, Brett D, Monaghan P, Whitehouse S, Rennie G, Rayner E, Cooper CS, Goodwin G. Functional domains of the SYT and SYT-SSX synovial sarcoma translocation proteins and co-localization with the SNF protein BRM in the nucleus. Human Molecular Genetics. Apr 1999, 8 (4): 585–91. PMID 10072425. doi:10.1093/hmg/8.4.585.
• Eid JE, Kung AL, Scully R, Livingston DM. p300 interacts with the nuclear proto-oncoprotein SYT as part of the active control of cell adhesion. Cell. Sep 2000, 102 (6): 839–48. PMID 11030627. doi:10.1016/S0092-8674(00)00072-6.
• Tamborini E, Agus V, Mezzelani A, Riva C, Sozzi G, Azzarelli A, Pierotti MA, Pilotti S. Identification of a novel spliced variant of the SYT gene expressed in normal tissues and in synovial sarcoma. British Journal of Cancer. Apr 2001, 84 (8): 1087–94. PMC 2363857 . PMID 11308259. doi:10.1054/bjoc.2000.1710.
• Brodin B, Haslam K, Yang K, Bartolazzi A, Xie Y, Starborg M, Lundeberg J, Larsson O. Cloning and characterization of spliced fusion transcript variants of synovial sarcoma: SYT/SSX4, SYT/SSX4v, and SYT/SSX2v. Possible regulatory role of the fusion gene product in wild type SYT expression. Gene. May 2001, 268 (1-2): 173–82. PMID 11368913. doi:10.1016/S0378-1119(01)00412-7.
• de Bruijn DR, dos Santos NR, Thijssen J, Balemans M, Debernardi S, Linder B, Young BD, Geurts van Kessel A. The synovial sarcoma associated protein SYT interacts with the acute leukemia associated protein AF10. Oncogene. May 2001, 20 (25): 3281–9. PMID 11423977. doi:10.1038/sj.onc.1204419.
• Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y. Protein-protein interaction panel using mouse full-length cDNAs. Genome Research. Oct 2001, 11 (10): 1758–65. PMC 311163 . PMID 11591653. doi:10.1101/gr.180101.
• Kato H, Tjernberg A, Zhang W, Krutchinsky AN, An W, Takeuchi T, Ohtsuki Y, Sugano S, de Bruijn DR, Chait BT, Roeder RG. SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones. The Journal of Biological Chemistry. Feb 2002, 277 (7): 5498–505. PMID 11734557. doi:10.1074/jbc.M108702200.
• Yang K, Lui WO, Xie Y, Zhang A, Skytting B, Mandahl N, Larsson C, Larsson O. Co-existence of SYT-SSX1 and SYT-SSX2 fusions in synovial sarcomas. Oncogene. Jun 2002, 21 (26): 4181–90. PMID 12037676. doi:10.1038/sj.onc.1205569.
• Imabayashi H, Mori T, Gojo S, Kiyono T, Sugiyama T, Irie R, Isogai T, Hata J, Toyama Y, Umezawa A. Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis. Experimental Cell Research. Aug 2003, 288 (1): 35–50. PMID 12878157. doi:10.1016/S0014-4827(03)00130-7.
• Perani M, Ingram CJ, Cooper CS, Garrett MD, Goodwin GH. Conserved SNH domain of the proto-oncoprotein SYT interacts with components of the human chromatin remodelling complexes, while the QPGY repeat domain forms homo-oligomers. Oncogene. Nov 2003, 22 (50): 8156–67. PMID 14603256. doi:10.1038/sj.onc.1207031.
• Iwasaki T, Koibuchi N, Chin WW. Synovial sarcoma translocation (SYT) encodes a nuclear receptor coactivator. Endocrinology. Sep 2005, 146 (9): 3892–9. PMID 15919756. doi:10.1210/en.2004-1513.
• Fernebro J, Francis P, Edén P, Borg A, Panagopoulos I, Mertens F, Vallon-Christersson J, Akerman M, Rydholm A, Bauer HC, Mandahl N, Nilbert M. Gene expression profiles relate to SS18/SSX fusion type in synovial sarcoma. International Journal of Cancer. Journal International Du Cancer. Mar 2006, 118 (5): 1165–72. PMID 16152617. doi:10.1002/ijc.21475.
• Perani M, Antonson P, Hamoudi R, Ingram CJ, Cooper CS, Garrett MD, Goodwin GH. The proto-oncoprotein SYT interacts with SYT-interacting protein/co-activator activator (SIP/CoAA), a human nuclear receptor co-activator with similarity to EWS and TLS/FUS family of proteins. The Journal of Biological Chemistry. Dec 2005, 280 (52): 42863–76. PMID 16227627. doi:10.1074/jbc.M502963200.
• Sun Y, Gao D, Liu Y, Huang J, Lessnick S, Tanaka S. IGF2 is critical for tumorigenesis by synovial sarcoma oncoprotein SYT-SSX1. Oncogene. Feb 2006, 25 (7): 1042–52. PMID 16247461. doi:10.1038/sj.onc.1209143.