G-四联体 (英语:G-quadruplex 、G-tetrads 或G4 -DNA )是一种由富含鸟嘌呤 的核酸序列所构成的四股型态。含有经由胡斯坦(Hoogsteen) 氢键 维持稳定,并由鸟嘌呤以正方形方式排列而成的结构。在方形中央有一个单价 阳离子 (通常是钾 )[ 1] 。这种结构可见于DNA 、RNA 、LNA (锁核酸)与PNA (肽核酸);根据形成四联体的各股的方向,可能有分子内 (intramolecular)、双分子 (bimolecular)或四分子(tetramolecular)等不同类型[ 2] 。
在四联体的结构中,我们可以根据四股的方向,将结构分为平行 和反平行 。
Structure of a G-quadruplex. Left: a G-tetrad. Right: an intramolecular G-quadruplex
3D Structure of the intramolecular human telomeric G-quadruplex in potassium solution (PDB ID 2HY9). The backbone is represented by a tube. The center of this structure contains three layers of G-tetrads. The hydrogen bonds in these layers are represented by blue dashed lines.
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