FK962是一种有机化合物，可用作体抑素释放的促进剂。它可以刺激神经生长和神经突伸长，并已在动物模型中进行了研究，在阿兹海默症和视神经病变等疾病的治疗上具有潜在应用。[1][2][3][4]
Quick Facts 识别信息, CAS号 ...
FK962 |
|
N-(1-acetylpiperidin-4-yl)-4-fluorobenzamide
|
| CAS号 | 283167-06-6  Y |
|---|
| PubChem CID | |
|---|
| ChemSpider | |
|---|
| UNII | |
|---|
| ChEMBL | |
|---|
|
| 化学式 | C14H17FN2O2 |
|---|
| 摩尔质量 | 264.30 g·mol−1 |
|---|
| 3D模型（JSmol） | |
|---|
CC(=O)N1CCC(CC1)NC(=O)C2=CC=C(C=C2)F
|
InChI=1S/C14H17FN2O2/c1-10(18)17-8-6-13(7-9-17)16-14(19)11-2-4-12(15)5-3-11/h2-5,13H,6-9H2,1H3,(H,16,19) Key:VBHVOHJOTMCSBQ-UHFFFAOYSA-N
|
Close
Tokita K, Inoue T, Yamazaki S, Wang F, Yamaji T, Matsuoka N, Mutoh S. FK962, a novel enhancer of somatostatin release, exerts cognitive-enhancing actions in rats. European Journal of Pharmacology. December 2005, 527 (1–3): 111–120. PMID 16325809. doi:10.1016/j.ejphar.2005.10.022. McCarthy AD, Owens IJ, Bansal AT, McTighe SM, Bussey TJ, Saksida LM. FK962 and donepezil act synergistically to improve cognition in rats: potential as an add-on therapy for Alzheimer's disease. Pharmacology, Biochemistry, and Behavior. March 2011, 98 (1): 76–80. PMID 21130801. S2CID 26055819. doi:10.1016/j.pbb.2010.11.019. Kishimoto Y, Yabuta C, Shearer TR, Azuma M. FK962 promotes neurite elongation and regeneration of cultured rat trigeminal ganglion cells: possible involvement of GDNF. Investigative Ophthalmology & Visual Science. August 2012, 53 (9): 5312–5319. PMID 22714891. doi:10.1167/iovs.11-8957. Nakajima E, Walkup RD, Shearer TR, Azuma M. FK962 induces neurite outgrowth in cultured monkey trigeminal ganglion cells. Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht von Graefes Archiv für Klinische und Experimentelle Ophthalmologie. January 2017, 255 (1): 107–112. PMID 27778122. S2CID 26043647. doi:10.1007/s00417-016-3525-5.
