FK962

FK962是一种有机化合物，可用作体抑素释放的促进剂。它可以刺激神经生长和神经突伸长，并已在动物模型中进行了研究，在阿兹海默症和视神经病变（英语：retinal neuropathy）等疾病的治疗上具有潜在应用。^[1][2][3][4]

FK962

识别信息
IUPAC命名法 N-(1-acetylpiperidin-4-yl)-4-fluorobenzamide
CAS号	283167-06-6  Y
PubChem CID	9816738
ChemSpider	7992488
UNII	25J7VT36F9
ChEMBL	ChEMBL4303387
化学信息
化学式	C14H17FN2O2
摩尔质量	264.30 g·mol−1
3D模型（JSmol（英语：JSmol））	交互式图像
SMILES CC(=O)N1CCC(CC1)NC(=O)C2=CC=C(C=C2)F
InChI InChI=1S/C14H17FN2O2/c1-10(18)17-8-6-13(7-9-17)16-14(19)11-2-4-12(15)5-3-11/h2-5,13H,6-9H2,1H3,(H,16,19) Key:VBHVOHJOTMCSBQ-UHFFFAOYSA-N

参考文献

1. Tokita K, Inoue T, Yamazaki S, Wang F, Yamaji T, Matsuoka N, Mutoh S. FK962, a novel enhancer of somatostatin release, exerts cognitive-enhancing actions in rats. European Journal of Pharmacology. December 2005, 527 (1–3): 111–120. PMID 16325809. doi:10.1016/j.ejphar.2005.10.022.
2. McCarthy AD, Owens IJ, Bansal AT, McTighe SM, Bussey TJ, Saksida LM. FK962 and donepezil act synergistically to improve cognition in rats: potential as an add-on therapy for Alzheimer's disease. Pharmacology, Biochemistry, and Behavior. March 2011, 98 (1): 76–80. PMID 21130801. S2CID 26055819. doi:10.1016/j.pbb.2010.11.019.
3. Kishimoto Y, Yabuta C, Shearer TR, Azuma M. FK962 promotes neurite elongation and regeneration of cultured rat trigeminal ganglion cells: possible involvement of GDNF. Investigative Ophthalmology & Visual Science. August 2012, 53 (9): 5312–5319. PMID 22714891. doi:10.1167/iovs.11-8957.
4. Nakajima E, Walkup RD, Shearer TR, Azuma M. FK962 induces neurite outgrowth in cultured monkey trigeminal ganglion cells. Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht von Graefes Archiv für Klinische und Experimentelle Ophthalmologie. January 2017, 255 (1): 107–112. PMID 27778122. S2CID 26043647. doi:10.1007/s00417-016-3525-5.