1,8-萘啶

1,8-萘啶（英语：1,8-Naphthyridine，也称为1,8-二氮杂萘）是萘啶（二氮杂萘，分子式C₈H₆N₂）的同分异构体之一^[2][3]。其衍生物有依诺沙星、萘啶酸、曲伐沙星等。1,8-萘啶在配位化学中是双核配体（英语：binucleating ligand），即与两个金属原子配位的配体。^[4][5]

1,8-萘啶
IUPAC名 1,8-Naphthyridine[1]
识别
CAS号	254-60-4
PubChem	136069
ChemSpider	119846
SMILES	C1=CC2=C(N=C1)N=CC=C2
Beilstein	109347
Gmelin	27124
EINECS	675-799-8
ChEBI	36628
性质
化学式	C8H6N2
摩尔质量	130.15 g·mol−1
外观	黄色固体
密度	1.359 g/cm3
熔点	98-99 °C（272 K）
危险性
GHS危险性符号
GHS提示词	Warning
H-术语	H315, H319, H335
P-术语	P261, P264, P271, P280, P302+352, P304+340, P305+351+338, P312, P321, P332+313, P337+313, P362, P403+233, P405
若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

参考文献

1. International Union of Pure and Applied Chemistry. Nomenclature of Organic Chemistry: IUPAC Recommendations and Preferred Names 2013. The Royal Society of Chemistry. 2014: 212. ISBN 978-0-85404-182-4. doi:10.1039/9781849733069.
2. Litvinov, Victor P.; Roman, Sergey V.; Dyachenko, Vladimir D. Naphthyridines. Structure, Physicochemical Properties and General Methods of Synthesis. Russian Chemical Reviews. 2000, 69 (3): 201–220. Bibcode:2000RuCRv..69..201L. S2CID 250827396. doi:10.1070/RC2000v069n03ABEH000553.
3. Dapporto, P.; Ghilardi, C. A.; Mealli, C.; Orlandini, A.; Pacinotti, S. Low-Temperature (163 K) Structure of 1,8-Naphthyridine, C₈H₆N₂. Acta Crystallographica Section C Crystal Structure Communications. 1984, 40 (5): 891–894. doi:10.1107/S0108270184006144.
4. Hua, Shao-An; Liu, Isiah Po-Chun; Hasanov, Hasan; Huang, Gin-Chen; Ismayilov, Rayyat Huseyn; Chiu, Chien-Lan; Yeh, Chen-Yu; Lee, Gene-Hsiang; Peng, Shie-Ming. Probing the electronic communication of linear heptanickel and nonanickel string complexes by utilizing two redox-active [Ni2(napy)4]3+ moieties. Dalton Transactions. 2010, 39 (16): 3890–6. PMID 20372713. doi:10.1039/b923125k.
5. Bera, Jitendra K.; Sadhukhan, Nabanita; Majumdar, Moumita. 1,8-Naphthyridine Revisited: Applications in Dimetal Chemistry. European Journal of Inorganic Chemistry. 2009, 2009 (27): 4023–4038. doi:10.1002/ejic.200900312.