阿拉普利(INN:alacepril)是一种ACE抑制剂药物,可用于治疗高血压。该药物代谢为卡托普利和去乙酰阿拉普利。[1]阿拉普利主要用于治疗高血压,在某些情况下用于治疗肾血管性高血压。它通常与其他药物结合使用,特别是其他降血压药物,如噻嗪类利尿剂,以最大限度地发挥其功效。[2]
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阿拉普利 |
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AHFS/Drugs.com | 国际药品名称 |
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给药途径 | 口服 |
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(2S)-2-[[(2S)-1-[(2S)-3-acetylsulfanyl-2-methylpropanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoic acid
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CAS号 | 74258-86-9 N |
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化学式 | C20H26N2O5S |
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摩尔质量 | 406.50 g·mol−1 |
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3D模型(JSmol) | |
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C[C@H](CSC(=O)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)O
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InChI=1S/C20H26N2O5S/c1-13(12-28-14(2)23)19(25)22-10-6-9-17(22)18(24)21-16(20(26)27)11-15-7-4-3-5-8-15/h3-5,7-8,13,16-17H,6,9-12H2,1-2H3,(H,21,24)(H,26,27)/t13-,16+,17+/m1/s1 YKey:FHHHOYXPRDYHEZ-COXVUDFISA-N Y
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在体内,当阿拉普利经历脱乙酰化时,它会失去类似于苯丙氨酸的分子,从而将其转化为卡托普利。[3]卡托普利通过两种方式发挥降血压作用。首先,它抑制血管紧张素1(一种前体分子)转化为血管紧张素II(一种使血管变窄的血管收缩剂)的过程。其次,卡托普利可以防止缓激肽的分解,缓激肽是一种自然松弛血管的血管舒张肽。[4]
Alacepril. IBM Micromedex. 24 August 2010 [23 June 2022].
Alacepril. DrugCentral online drug compendium. [13 April 2024]. It is an angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. It used for the treatment of essential or renovascular hypertension (usually administered with other drugs, particularly thiazide diuretics).
Campese VM, Lakdawala RS. The Challenges of Blood Pressure Control in Dialysis Patients. Nissenson AR, Fine RN (编). Handbook of dialysis therapy 5th. Philadelphia, PA: Elsevier. 2017. ISBN 978-0-323-39154-2. doi:10.1016/B978-0-323-39154-2.00053-9. The sulfhydryl agents, such as alacepril, delapril, and moveltopril, are prodrugs and thus are converted to captopril in vivo. These sulfhydryl-containing compounds have a slower onset and longer duration of action than captopril.