维基百科中的医学内容
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医学声明。
痕量胺相关受体（英语：Trace amine-associated receptors，简称TAAR，有时也称trace amine receptors）是一种G蛋白偶联受体，于2001年发现。[1][2][3]其中，人类身上六个功能性痕量胺相关受体中的第一个，TAAR1，因为是痕量胺的内源受体这一独特功能而在医学界、制药研究方面备受瞩目——痕量胺是苯丙氨酸和色氨酸以及苯丙胺、甲基苯丙胺等兴奋剂的痕量代谢产物。[4][5][6][7][8][9]2004年的一份研究显示，哺乳动物的TAAR1也是甲状腺激素的脱羧碘化代谢产物。[6] 脊椎动物的TAAR2至TAAR9也可用作嗅觉受器，探测挥发性胺。[10]
Borowsky B, Adham N, Jones KA, Raddatz R, Artymyshyn R, Ogozalek KL, Durkin MM, Lakhlani PP, Bonini JA, Pathirana S, Boyle N, Pu X, Kouranova E, Lichtblau H, Ochoa FY, Branchek TA, Gerald C. Trace amines: identification of a family of mammalian G protein-coupled receptors. PNAS. 2001, 98 (16): 8966–71. PMC 55357 
. PMID 11459929. doi:10.1073/pnas.151105198. Bunzow JR, Sonders MS, Arttamangkul S, Harrison LM, Zhang G, Quigley DI, Darland T, Suchland KL, Pasumamula S, Kennedy JL, Olson SB, Magenis RE, Amara SG, Grandy DK. Amphetamine, 3,4-methylenedioxymethamphetamine, lysergic acid diethylamide, and metabolites of the catecholamine neurotransmitters are agonists of a rat trace amine receptor. Mol. Pharmacol. 2001, 60 (6): 1181–8. PMID 11723224. doi:10.1124/mol.60.6.1181. Scanlan TS, Suchland KL, Hart ME, Chiellini G, Huang Y, Kruzich PJ, Frascarelli S, Crossley DA, Bunzow JR, Ronca-Testoni S, Lin ET, Hatton D, Zucchi R, Grandy DK. 3-Iodothyronamine is an endogenous and rapid-acting derivative of thyroid hormone. Nat. Med. 2004, 10 (6): 638–42. PMID 15146179. doi:10.1038/nm1051. Hart ME, Suchland KL, Miyakawa M, Bunzow JR, Grandy DK, Scanlan TS. Trace amine-associated receptor agonists: synthesis and evaluation of thyronamines and related analogues. J. Med. Chem. 2006, 49 (3): 1101–12. PMID 16451074. doi:10.1021/jm0505718.
