甘草素

甘草素
	IUPAC名; (2S)-4′,7-二羟基黄酮-4-酮
	系统名; (2S)-7-羟基-2-(4-羟基苯基)-2,3-二氢-4H-1-苯并吡喃-4-酮
识别
CAS号	578-86-9
PubChem	114829
ChemSpider	102790
SMILES	O=C2c3c(O[C@H](c1ccc(O)cc1)C2)cc(O)cc3;
InChI	1/C15H12O4/c16-10-3-1-9(2-4-10)14-8-13(18)12-6-5-11(17)7-15(12)19-14/h1-7,14,16-17H,8H2/t14-/m0/s1;
InChIKey	FURUXTVZLHCCNA-AWEZNQCLBC
ChEBI	28777
KEGG	C09762
性质
化学式	C15H12O4
摩尔质量	256.25 g·mol−1
	若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

甘草素（英语：Liquiritigenin）或译为甘草醇，是一种黄烷酮，从‘甘草’（学名：Glycyrrhiza uralensis）中分离出来，在甘草属植物中广泛存在，包括‘光果甘草’（学名：Glycyrrhiza glabra）。^[1]它是一种雌激素化合物，作为雌激素受体（ER）的ERβ亚型的选择性激动剂，尽管在足够高的浓度下据报导，也能作为ERα的部分激动剂。^[2] 它也具有利胆作用。^[1]

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甘草素，NADPH：氧氧化还原酶（羟基化，芳基迁移）是一种酶，使用甘草素，O₂，NADPH和H⁺产生2,7,4'-三羟基异黄酮，H₂O和NADP⁺。

参见

Menerba
Prinaberel (ERB-041)
Diarylpropionitrile (DPN)
WAY-200070
PHTPP
(R,R)-Tetrahydrochrysene ((R,R)-THC)
丙基吡唑三醇 (PPT)
Methylpiperidinopyrazole (MPP)

参考

[1]
Kim, YW; Kang, HE; Lee, MG; Hwang, SJ; Kim, SC; Lee, CH; Kim, SG. Liquiritigenin, a flavonoid aglycone from licorice, has a choleretic effect and the ability to induce hepatic transporters and phase-II enzymes. American Journal of Physiology. Gastrointestinal and Liver Physiology. 2009, 296 (2): G372–81. PMID 19074639. doi:10.1152/ajpgi.90524.2008.
[2]
Mersereau, Jennifer E.; Levy, Nitzan; Staub, Richard E.; Baggett, Scott; Zogric, Tetjana; Chow, Sylvia; Ricke, William A.; Tagliaferri, Mary; et al. Liquiritigenin is a plant-derived highly selective estrogen receptor β agonist. Molecular and Cellular Endocrinology. 2008, 283 (1–2): 49–57. PMC 2277338 . PMID 18177995. doi:10.1016/j.mce.2007.11.020.

这是一篇有关芳香化合物的小作品。您可以通过编辑或修订扩充其内容。

[Kim-1] [1]
Kim, YW; Kang, HE; Lee, MG; Hwang, SJ; Kim, SC; Lee, CH; Kim, SG. Liquiritigenin, a flavonoid aglycone from licorice, has a choleretic effect and the ability to induce hepatic transporters and phase-II enzymes. American Journal of Physiology. Gastrointestinal and Liver Physiology. 2009, 296 (2): G372–81. PMID 19074639. doi:10.1152/ajpgi.90524.2008.

[2] [2]
Mersereau, Jennifer E.; Levy, Nitzan; Staub, Richard E.; Baggett, Scott; Zogric, Tetjana; Chow, Sylvia; Ricke, William A.; Tagliaferri, Mary; et al. Liquiritigenin is a plant-derived highly selective estrogen receptor β agonist. Molecular and Cellular Endocrinology. 2008, 283 (1–2): 49–57. PMC 2277338 . PMID 18177995. doi:10.1016/j.mce.2007.11.020.

[1]

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