TLR2

Toll样受体2（英语：Toll-like receptor 2）是由人类基因 TLR2 编码的蛋白质^[5]，是一种膜蛋白质和受体，也被称为CD282（分化簇282，cluster of differentiation 282），是Toll样受体（TLR）家族的成员，在免疫系统中起到重要作用。

TLR2
已知的结构 PDB 直系同源搜索: PDBe RCSB PDBID列表 1FYW、​1FYX、​1O77、​2Z7X、​2Z80
识别号
别名	TLR2；, CD282, TIL4, toll like receptor 2
外部ID	OMIM：603028 MGI：1346060 HomoloGene：20695 GeneCards：TLR2
基因位置（人类） 染色体 4号染色体[1] 基因座 4q31.3 起始 153,684,070 bp[1] 终止 153,706,260 bp[1]
基因位置（小鼠） 染色体 小鼠3号染色体[2] 基因座 3|3 E3 起始 83,743,579 bp[2] 终止 83,749,074 bp[2]
RNA表达模式
查阅更多表达数据
基因本体 分子功能 • pattern recognition receptor activity • lipopolysaccharide binding • Toll-like receptor binding • triacyl lipopeptide binding • 血浆蛋白结合 • peptidoglycan binding • protein heterodimerization activity • lipopolysaccharide immune receptor activity • transmembrane signaling receptor activity • lipopeptide binding 细胞组分 • 细胞质 • integral component of membrane • phagocytic vesicle membrane • 高尔基体 • 膜 • intrinsic component of plasma membrane • 细胞膜 • Toll-like receptor 1-Toll-like receptor 2 protein complex • integral component of plasma membrane • 脂筏模型 • cytoplasmic vesicle • cell projection • cell surface • cell body 生物学过程 • interleukin-10 production • positive regulation of interferon-beta production • defense response to Gram-positive bacterium • positive regulation of interleukin-18 production • positive regulation of toll-like receptor signaling pathway • toll-like receptor TLR1:TLR2 signaling pathway • positive regulation of inflammatory response • cellular response to bacterial lipopeptide • positive regulation of interleukin-12 production • immune system process • detection of diacyl bacterial lipopeptide • cellular response to diacyl bacterial lipopeptide • I-kappaB phosphorylation • positive regulation of nitric-oxide synthase biosynthetic process • MyD88-dependent toll-like receptor signaling pathway • cellular response to triacyl bacterial lipopeptide • detection of triacyl bacterial lipopeptide • positive regulation of Wnt signaling pathway • positive regulation of gene expression • cellular response to lipoteichoic acid • positive regulation of NF-kappaB transcription factor activity • 免疫反应 • positive regulation of interleukin-8 production • positive regulation of interleukin-6 production • positive regulation of tumor necrosis factor production • positive regulation of chemokine production • 先天免疫系统 • inflammatory response • toll-like receptor TLR6:TLR2 signaling pathway • response to molecule of bacterial origin • 信号转导 • positive regulation of transcription by RNA polymerase II • 细胞凋亡 • response to lipopolysaccharide • response to progesterone • toll-like receptor signaling pathway • response to insulin • central nervous system myelin formation • nitric oxide metabolic process • response to fatty acid • leukotriene metabolic process • toll-like receptor 2 signaling pathway • positive regulation of oligodendrocyte differentiation • response to bacterial lipoprotein • negative regulation of cell population proliferation • response to toxic substance • response to hypoxia • positive regulation of interleukin-10 production • lipopolysaccharide-mediated signaling pathway • microglial cell activation Sources:Amigo / QuickGO
直系同源
物种	人类	小鼠
Entrez	7097	24088
Ensembl	ENSG00000137462	ENSMUSG00000027995
UniProt	O60603	Q9QUN7
mRNA​序列	​NM_003264 ​NM_001318787 ​NM_001318789 ​NM_001318790 ​NM_001318791 ​NM_001318793 ​NM_001318795 ​NM_001318796	NM_011905
蛋白序列	NP_001305716 ​NP_001305718 ​NP_001305719 ​NP_001305720 ​NP_001305722 ​NP_001305724 ​NP_001305725 ​NP_003255	NP_036035
基因位置​（UCSC）	Chr 4: 153.68 – 153.71 Mb	Chr 3: 83.74 – 83.75 Mb
PubMed​查找	[3]	[4]
维基数据
查看/编辑人类 查看/编辑小鼠

参考文献

1. GRCh38: Ensembl release 89: ENSG00000137462 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027995 - Ensembl, May 2017
3. Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Rock FL, Hardiman G, Timans JC, Kastelein RA, Bazan JF. A family of human receptors structurally related to Drosophila Toll. Proceedings of the National Academy of Sciences of the United States of America. January 1998, 95 (2): 588–93. Bibcode:1998PNAS...95..588R. PMC 18464 . PMID 9435236. doi:10.1073/pnas.95.2.588.

延伸阅读

• Aderem A, Ulevitch RJ. Toll-like receptors in the induction of the innate immune response. Nature. August 2000, 406 (6797): 782–7. PMID 10963608. S2CID 4410405. doi:10.1038/35021228.
• Ey B, Eyking A, Klepak M, Salzman NH, Göthert JR, Rünzi M, Schmid KW, Gerken G, Podolsky DK, Cario E. Loss of TLR2 worsens spontaneous colitis in MDR1A deficiency through commensally induced pyroptosis. J. Immunol. June 2013, 190 (11): 5676–88. PMC 3659955 . PMID 23636052. doi:10.4049/jimmunol.1201592.
• Muzio M, Polentarutti N, Bosisio D, Manoj Kumar PP, Mantovani A. Toll-like receptor family and signalling pathway. Biochemical Society Transactions. October 2000, 28 (5): 563–6. PMID 11044375. doi:10.1042/bst0280563.
• Hallman M, Rämet M, Ezekowitz RA. Toll-like receptors as sensors of pathogens. Pediatric Research. September 2001, 50 (3): 315–21. PMID 11518816. S2CID 24420705. doi:10.1203/00006450-200109000-00004 .
• Dziarski R, Gupta D. Role of MD-2 in TLR2- and TLR4-mediated recognition of Gram-negative and Gram-positive bacteria and activation of chemokine genes. Journal of Endotoxin Research. 2001, 6 (5): 401–5. PMID 11521063. doi:10.1177/09680519000060050101 .
• Lien E, Ingalls RR. Toll-like receptors. Critical Care Medicine. January 2002, 30 (1 Suppl): S1–11. PMID 11782555. doi:10.1097/00003246-200201001-00001.
• Xu D, Komai-Koma M, Liew FY. Expression and function of Toll-like receptor on T cells. Cellular Immunology. February 2005, 233 (2): 85–9. PMID 15950961. doi:10.1016/j.cellimm.2005.04.019.
• Lorenz E. TLR2 and TLR4 expression during bacterial infections. Current Pharmaceutical Design. 2007, 12 (32): 4185–93. PMID 17100621. doi:10.2174/138161206778743547.

外部链接

• 医学主题词表（MeSH）：TLR2+protein,+human