CD18

整联蛋白β-2（英语：Integrin beta-2，CD18）是一个由人类基因 ITGB2 编码的蛋白质，是整联蛋白的一种β亚基。

CD18
已知的结构 PDB 直系同源搜索: PDBe RCSB PDBID列表 1L3Y、​1YUK、​2JF1、​2P26、​2P28、​3K6S、​3K71、​3K72、​2V7D、​4NEH、​4NEN、​5E6X、​5E6V、​5E6S、​5E6R、​5E6W、​5ES4、​5E6U
识别号
别名	ITGB2；, CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7, integrin subunit beta 2
外部ID	OMIM：600065 MGI：96611 HomoloGene：20092 GeneCards：ITGB2
相关疾病
leukocyte adhesion deficiency-1[1]
基因位置（人类） 染色体 21号染色体[2] 基因座 21q22.3 起始 44,885,953 bp[2] 终止 44,931,989 bp[2]
基因位置（小鼠） 染色体 小鼠10号染色体[3] 基因座 10 C1|10 39.72 cM 起始 77,366,086 bp[3] 终止 77,401,542 bp[3]
RNA表达模式
查阅更多表达数据
基因本体 分子功能 • 大分子复合物结合 • 金属离子结合 • 血浆蛋白结合 • protein heterodimerization activity • ICAM-3 receptor activity • protein kinase binding • cell adhesion molecule binding • heat shock protein binding • amyloid-beta binding • complement component C3b binding • integrin binding • signaling receptor activity • cargo receptor activity 细胞组分 • integral component of membrane • 细胞外囊泡 • integrin alphaL-beta2 complex • 膜 • 细胞膜 • receptor complex • cell surface • integrin complex • 外排体 • specific granule membrane • tertiary granule membrane • ficolin-1-rich granule membrane • 粘着斑 • external side of plasma membrane • integrin alphaM-beta2 complex • plasma membrane raft • 脂筏模型 • cytoplasmic region • 大分子复合体 生物学过程 • leukocyte cell-cell adhesion • endodermal cell differentiation • toll-like receptor 4 signaling pathway • positive regulation of nitric oxide biosynthetic process • heterotypic cell-cell adhesion • cell-cell signaling • 老化 • receptor internalization • leukocyte migration involved in inflammatory response • natural killer cell activation • cellular response to low-density lipoprotein particle stimulus • extracellular matrix organization • receptor clustering • positive regulation of angiogenesis • neutrophil chemotaxis • 细胞粘附 • positive regulation of NF-kappaB transcription factor activity • regulation of cell shape • regulation of immune response • cellular extravasation • integrin-mediated signaling pathway • cell-matrix adhesion • inflammatory response • endothelial cell migration • leukocyte migration • regulation of peptidyl-tyrosine phosphorylation • 细胞凋亡 • 吞噬作用 • neutrophil degranulation • microglial cell activation • 受体介导的内吞作用 • phagocytosis, engulfment • 细胞迁移 • cytokine-mediated signaling pathway • positive regulation of superoxide anion generation • cell adhesion mediated by integrin • positive regulation of neutrophil degranulation • negative regulation of dopamine metabolic process • positive regulation of protein targeting to membrane • amyloid-beta clearance • cell-cell adhesion • cell-cell adhesion via plasma-membrane adhesion molecules • positive regulation of neuron death • positive regulation of microglial cell activation • neutrophil migration • positive regulation of prostaglandin-E synthase activity • positive regulation of leukocyte adhesion to vascular endothelial cell Sources:Amigo / QuickGO
直系同源
物种	人类	小鼠
Entrez	3689	16414
Ensembl	ENSG00000160255	ENSMUSG00000000290
UniProt	P05107	P11835
mRNA​序列	​NM_000211 ​NM_001127491 ​NM_001303238	NM_008404
蛋白序列	NP_000202 ​NP_001120963 ​NP_001290167	NP_032430
基因位置​（UCSC）	Chr 21: 44.89 – 44.93 Mb	Chr 10: 77.37 – 77.4 Mb
PubMed​查找	[4]	[5]
维基数据
查看/编辑人类 查看/编辑小鼠

能与下列四种整联蛋白α亚基搭配形成四种整联蛋白：

• 淋巴细胞功能性抗原1，LFA-1 (搭配 CD11a)
• 巨噬细胞抗原的1 (搭配 CD11b)
• 整联蛋白αXβ2 (搭配 CD11c)
• 整联蛋白αDβ2 (搭配 CD11d)

相互作用

CD18已经与下列蛋白质进行交互作用 ：

• FHL2^[6]
• GNB2L1^[7]
• ICAM-1^[8][9][10]
• PSCD1^[11][12]

参考文献

1. 與CD18相關的疾病；在維基數據上查看/編輯參考.
2. GRCh38: Ensembl release 89: ENSG00000160255 - Ensembl, May 2017
3. GRCm38: Ensembl release 89: ENSMUSG00000000290 - Ensembl, May 2017
4. Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
6. Wixler V, Geerts D, Laplantine E, Westhoff D, Smyth N, Aumailley M, Sonnenberg A, Paulsson M. The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes. The Journal of Biological Chemistry. October 2000, 275 (43): 33669–78. PMID 10906324. doi:10.1074/jbc.M002519200.
7. Liliental J, Chang DD. Rack1, a receptor for activated protein kinase C, interacts with integrin beta subunit. The Journal of Biological Chemistry. Jan 1998, 273 (4): 2379–83. PMID 9442085. doi:10.1074/jbc.273.4.2379.
8. Kotovuori A, Pessa-Morikawa T, Kotovuori P, Nortamo P, Gahmberg CG. ICAM-2 and a peptide from its binding domain are efficient activators of leukocyte adhesion and integrin affinity. Journal of Immunology. June 1999, 162 (11): 6613–20. PMID 10352278.
9. Lu C, Takagi J, Springer TA. Association of the membrane proximal regions of the alpha and beta subunit cytoplasmic domains constrains an integrin in the inactive state. The Journal of Biological Chemistry. May 2001, 276 (18): 14642–8. PMID 11279101. doi:10.1074/jbc.M100600200.
10. Huang C, Springer TA. A binding interface on the I domain of lymphocyte function-associated antigen-1 (LFA-1) required for specific interaction with intercellular adhesion molecule 1 (ICAM-1). The Journal of Biological Chemistry. August 1995, 270 (32): 19008–16. PMID 7642561. doi:10.1074/jbc.270.32.19008.
11. Rietzler M, Bittner M, Kolanus W, Schuster A, Holzmann B. The human WD repeat protein WAIT-1 specifically interacts with the cytoplasmic tails of beta7-integrins. The Journal of Biological Chemistry. October 1998, 273 (42): 27459–66. PMID 9765275. doi:10.1074/jbc.273.42.27459.
12. Geiger C, Nagel W, Boehm T, van Kooyk Y, Figdor CG, Kremmer E, Hogg N, Zeitlmann L, Dierks H, Weber KS, Kolanus W. Cytohesin-1 regulates beta-2 integrin-mediated adhesion through both ARF-GEF function and interaction with LFA-1. The EMBO Journal. June 2000, 19 (11): 2525–36. PMC 212768 . PMID 10835351. doi:10.1093/emboj/19.11.2525.

延伸阅读

外部链接

• MeSH（医学主题词）
  上面的CD18+antigen
• ITGB2 信息的链接在 单元的移徙网关
• Human ITGB2 genome location and ITGB2 gene details page in the UCSC Genome Browser（英语：UCSC Genome Browser）.