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Mmenyuko wa kikemia, (pia utendanaji wa kikemia[1]; kwa Kiingereza: chemical reaction) ni mchakato ambao unasababisha mabadiliko ya dutu ya kikemia kuwa dutu tofauti.
Mfano mmojawapo ni moto (mmenyuko kati ya oksijeni hewani na kampaundi za kaboni).
Kimsingi katika mimenyuko hiyo elektroni za dutu zinazotendana zinahama na kuunda au kuondoa muungo kemia kati ya atomu husika. Mchakato ama unahitaji nishati au unaachana na nishati. Viini vya atomu havibadiliki isipokuwa kama elementi zinazoshiriki ni nururifu na nzito sana na hivyo si thabiti.
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