221 SM nyaéta taun ka-221 Saméméh Maséhi dina Kalénder Gregorian.
| Kalénder Gregorian | 221 SM |
| Ab urbe condita | 533 |
| Kalénder Arménia | N/A |
| Kalénder Cina | 2416/2476 ([[Daur séksagenari|]]年) — nepi ka — 2417/2477([[Daur séksagenari|]]年) |
| Kalénder Étiopia | -228 – -227 |
| Kalénder Yahudi | 3540 – 3541 |
| Kalénder Hindu | |
| - Vikram Samvat | -165 – -164 |
| - Shaka Samvat | N/A |
| Kalénder Iran | 842 BP – 841 BP |
| Kalénder Islam | 868 SH – 867 SH |
| Kalénder Jepang | |
| - Taun penjajahan | Kōki 440 (皇紀440年) |
| - Jaman Jōmon | 9780 |
| Kalénder panonpoé Thai | 323 |
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