Métionin

Métionin (lambangna Met atawa M)^[3] (/mɪˈθaɪəniːn/)^[4] nyaéta asam amino ésénsial pikeun manusa. Salaku prékursor asam amino sistéin jeung taurin, sanyawa multiguna sarupaning SAM-e, jeung antioksidan penting glutation, métionin mancén peran penting dina métabolisme jeung kaséhatan rupa-rupa spésiés.

Métionin

Rumus rangka bentuk kanonik métionin
Modél bal-jeung-tongkat modél ngeusi-rohang
Wasta
Wasta IUPAC Métionin
Wasta lian Asam 2-amino-4-(métiltio)butanoat
Pananda
Nomer CAS	L: 63-68-3 Y D/L: 59-51-8 Y D: 348-67-4 Y
Modél 3D (JSmol)	L: Gambar interaktif L Zwitterion: Gambar interaktif
Abbreviations	Met, M
ChEBI	L: CHEBI:16643 Y D/L: CHEBI:16811 Y D: CHEBI:16867 Y
ChEMBL	L: ChEMBL42336 Y
ChemSpider	L: 5907 Y D/L: 853 Y D: 76512 Y
DrugBank	L: DB00134 Y
ECHA InfoCard	100.000.393
Nomer EC	200-432-1
KEGG	L: C00073 Y
PubChem CID	L: 6137 D/L: 876 D: 84815
UNII	L: AE28F7PNPL Y D/L: 73JWT2K6T3 Y D: 868496F25R Y
CompTox Dashboard (EPA)	L: DTXSID9020821
InChI InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1 Y Key: FFEARJCKVFRZRR-BYPYZUCNSA-N Y D/L: Key: FFEARJCKVFRZRR-UHFFFAOYSA-N D: Key: FFEARJCKVFRZRR-SCSAIBSYSA-N
SMILES L: CSCC[C@H](N)C(=O)O L Zwitterion: CSCC[C@H]([NH3+])C(=O)[O-]
Sipat[1]
Rumus kimia	C5H11NO2S
Massa molar	14921 g·mol−1
Panampilan	White crystalline powder
Dénsitas	1.340 g/cm3
Titik lebur	281 °C (538 °F; 554 K) decomposes
Kelarutan dina cai	Soluble
Kaasaman (pKa)	2.28 (carboxyl), 9.21 (amino)[2]
Farmakologi
Kode ATC	V03AB26 (WHO) QA05BA90 (WHO), QG04BA90 (WHO)
Iwal disebutkeun séjén, data nu dipidangkeun keur matéri dina kaayaan baku (dina 25 °C, 100 kPa).
Rujukan kotak info

Métionin ogé penting dina angiogenesis, tumuwuhna pembuluh getih. Supleméntasi métionin bisa natambaan anu karacunan tambaga.^[5] Sabalikna, asupan métionin anu kaleuleuwihi, donor gugus métil dina métilasi DNA, tumali jeung tumuwuhna kangker dina sababaraha panalungtikan.^[6][7] Métionin munggaran diisolasi taun 1921 ku John Howard Mueller.^[8]

Watek biokimia

Métionin (lambangna Met atawa M; dikode ku kodon AUG) téh asam α-amino anu dipaké dina biosintésis protéin. Ieu ngandung gugus karboksil (dina wangun kurang proton −COO⁻ dina kaayaan pH biologis), gugus amino (dina wangun leuwih proton −NH₃⁺ dina kaayaan pH biologis) dina α-posisi ti gugus karboksil, sarta ranté gigir S-métil tioéter, kagolongkeun kana asam amino nonpolar alipatik.

Dina gén inti eukariot jeung Archaea, métionin nyandi pikeun kodon mitembeyan, hartina nandaan ngamimitian daérah koding jeung asam amino munggaran anu diproduksi dina polipéptida nalika translasi mRNA.^[9]

Baca ogé

• Allantoin
• Formilmétionin
• Oksidasi métionin
• Karacunan parasétamol
• S-Métilsistéin

Rujukan

1. Citakan:RubberBible62nd.
2. Dawson, Rex M. C.; Elliott, Daphne C.; Elliott, William H.; Jones, K. M. (1959). Data for Biochemical Research. Oxford: Clarendon Press. Unknown parameter |name-list-style= ignored (bantuan)
3. "Nomenclature and Symbolism for Amino Acids and Peptides". IUPAC-IUB Joint Commission on Biochemical Nomenclature. 1983. Diarsipkan dari versi asli tanggal 9 October 2008. Diakses tanggal 5 March 2018. Unknown parameter |url-status= ignored (bantuan) Archived 9 Oktober 2008 di Wayback Machine
4. "Methionine". Oxford University Press. Archived 2018-01-27 di Wayback Machine
5. "Methionine". WebMD.
6. "A review of methionine dependency and the role of methionine restriction in cancer growth control and life-span extension". Cancer Treatment Reviews 38 (6): 726–36. 2012. doi:10.1016/j.ctrv.2012.01.004. PMID 22342103.
7. "Methionine dependency and cancer treatment". Cancer Treatment Reviews 29 (6): 489–99. 2003. doi:10.1016/S0305-7372(03)00118-X. PMID 14585259.
8. Pappenheimer AM (1987). "A Biographical Memoir of John Howard Mueller" (PDF). Washington D.C.: National Academy of Sciences. Unknown parameter |vauthors= ignored (bantuan)
9. "Amino acids biosynthesis and nitrogen assimilation pathways: a great genomic deletion during eukaryotes evolution". BMC Genomics 12 Suppl 4: S2. December 2011. doi:10.1186/1471-2164-12-S4-S2. PMC 3287585. PMID 22369087. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3287585.

Tutumbu kaluar

• Rudra, M. N.; Chowdhury, L. M. (30 September 1950). "Methionine Content of Cereals and Legumes". Nature 166 (568): 568. Bibcode 1950Natur.166..568R. doi:10.1038/166568a0. PMID 14780151.