Gonadotropin-oslobađajući hormon (), takođe poznat kao (engl. ) i luliberin ili gonadoliberin, je trofični peptidni hormon koji je odgovoran za oslobađanje folikul-stimulišućeg hormona () i luteinizujućeg hormona () iz prednjeg režnja hipofize. se sintetiše i oslobađa iz neurona hipotalamusa. Ovaj peptid pripada familiji gonadotropin oslobađajućih hormona.
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Затвори
Gen, , za prekurzor je lociran na hromozomu 8. Kod sisara, linearni dekapeptidni krajnji proizvod se sintetiše iz 92-aminokiselinskog prohormona u preoptičkom prednjem hipotalamusu
strukturu su objasnili Nobelovci Rodžer Guilemin i Andru V. Schali 1977. godine: piro
se smatra neurohormonom, hormonom koji proizvode specifične neuronske ćelije i otpuštaju ga na njihovim neuronskim završecima. Ključna oblast za produkciju je preoptička oblast hipotalamusa, koja sadrži većinu -izlučujućih neurona. neuroni nastaju u nosu i migriraju u mozak, gde se rasprostiru po medijalnom septumu i hipotalamusu. Oni su povezani vrlo dugim (>1-milimetra dugačkim) dendritima. Oni su grupisani tako da primaju zajednički sinaptički input, što im omogućava da sinhronizuju oslobađanje.[1]
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