Alfa-2A adrenergički receptor

Alfa-2A adrenergički receptor (α_2A adrenoceptor, ADRA2A) je alfa-2 adrenergički receptor. On je kodiran humanim genom.^[1]

Adrenergički alfa-2A receptor
prikaz baziran na 1hll​.
Dostupne strukture
1hll​, 1ho9​, 1hod​, 1hof​
Identifikatori
Simboli	ADRA2A; ADRA2; ADRA2R; ADRAR; ALPHA2AAR; ZNF32
Vanjski ID	OMIM: 104210 MGI: 87934 HomoloGene: 47944 IUPHAR: α2A-adrenoceptor GeneCards: ADRA2A Gene
Ontologija gena Molekularna funkcija • aktivnost rodopsinu-sličnog receptora • receptorska aktivnost • adrenoceptorska aktivnost • aktivnost alfa2-adrenergičkog receptora • proteinsko vezivanje • aktivnost regulatora kalijumskog kanala Celularna komponenta • ćelijska membrana • integralno sa ćelijskom membranom Biološki proces • aktivacija MAPK aktivnosti • ćelijska motilnost • prenos signala • signalni put G-protein spregnutog receptora • negativna regulacija aktivnosti adenilat ciklaze • transdukcija Ro protein signala • pozitivna regulacija ćelijske proliferacije • aktinska citoskeletonska organizacija i biogeneza • odgovor na strah
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta	Čovek	Miš
Entrez	150	11551
Ensembl	ENSG00000150594	ENSMUSG00000033717
UniProt	P08913	Q1HL33
RefSeq (mRNA)	NM_000681	XM_974141
RefSeq (protein)	NP_000672	XP_979235
Lokacija (UCSC)	Chr 10: 112.83 - 112.83 Mb	Chr 19: 54.1 - 54.1 Mb
PubMed pretraga

Receptor

Alfa-2-adrenergički receptori su 3 visoko homologna podtipa: alfa_2A, alfa_2B, i alfa_2C. Ti receptori imaju kritičnu ulogu u regulaciji otpuštanja neurotransmitera iz simpatičkih nerva i iz adrenergičkih neurona centralnog nervnog sistema. Ispitivanja na miševima su pokazala da su oba, alfa_2A i alfa_2C, podtipa neophodna za normalnu presinaptičku kontrolu otpuštanja transmitera iz simpatičkih nerva u srcu i iz centralnih noradrenergičkih neurona. Alfa_2A podtip inhibira otpuštanje transmitera na visokim stimulacionim frekvencijama, dok alfa_2C podtip modulira neurotransmisiju na niskim nivoima nervne aktivnosti.

Gen

Ovaj gen kodira alfa_2A tip receptora. On ne sadrži introne.^[1]

Selektivni ligandi

Agonisti

• Gvanfacin
• Klonidin

Antagonisti

• Johimbin

Vidi još

• Adrenergički receptor

Reference

1. „Entrez Gene: ADRA2A adrenergic, alpha-2A-, receptor”.

Literatura

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Spoljašnje veze

• „α_2A-adrenoceptor”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано из оригинала 02. 04. 2015. г.