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Src (gen)

Src (gen)

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Src (gen)
InteractionsReferenceLiteraturaVidi još

je proto-onkogenska tirozinska kinaza. su otkrili Mihael Bišop i Harold Varmus. Za ovo otkriće im je dodeljena Nobelova nagrada za fiziologiju ili medicinu 1989. godine.[1] Ova kinaza pripada familiji nespecifičnih proteinskih tirozinskih kinaza koja se naziva familijom kinaza. Otkriće porodice proteina je imalo presudnu ulogu u modernom shvatanju rak kao bolesti u kojoj se inače zdrava ćelijska signalizacija pokvari.

Кратке чињенице sarkoma viralni onkogeni homolog (avijarni), Dostupne strukture ...
sarkoma viralni onkogeni homolog (avijarni)
PDB prikaz baziran na 1a07​.
Dostupne strukture
1a07​, 1a08​, 1a09​, 1a1a​, 1a1b​, 1a1c​, 1a1e​, 1bkl​, 1bkm​, 1f1w​, 1f2f​, 1fmk​, 1hcs​, 1hct​, 1is0​, 1kc2​, 1ksw​, 1nlo​, 1nlp​, 1nzl​, 1nzv​, 1o41​, 1o42​, 1o43​, 1o44​, 1o45​, 1o46​, 1o47​, 1o48​, 1o49​, 1o4a​, 1o4b​, 1o4c​, 1o4d​, 1o4e​, 1o4f​, 1o4g​, 1o4h​, 1o4i​, 1o4j​, 1o4k​, 1o4l​, 1o4m​, 1o4n​, 1o4o​, 1o4p​, 1o4q​, 1o4r​, 1p13​, 1prl​, 1prm​, 1qwe​, 1qwf​, 1rlp​, 1rlq​, 1sha​, 1shb​, 1shd​, 1skj​, 1spr​, 1sps​, 1srl​, 1srm​, 1y57​, 1yi6​, 1yoj​, 1yol​, 1yom​, 2bdf​, 2bdj​, 2h8h​, 2hwo​, 2hwp​, 2oiq​, 2ptk​, 2src​
Identifikatori
Simboli SRC; ASV; SRC1; c-SRC; p60-Src
Vanjski ID OMIM: 190090 MGI: 98397 HomoloGene: 21120 GeneCards: SRC Gene
Ontologija gena
Molekularna funkcija • nukleotidno vezivanje
• aktivnost proteinske-tirozinske kinaze
• aktivnost SH3/SH2 adaptera
• proteinsko vezivanje
• ATP vezivanje
• aktivnost transferaze
• vezivanje SH2 domena
Celularna komponenta • membrana
• integralno sa membranom
Biološki proces • proteinska aminokiselinka fosforilacija
• formiranje signalnog kompleksa
• kaskada proteinskih kinaza
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta Čovek Miš
Entrez 6714 20779
Ensembl ENSG00000197122 ENSMUSG00000027646
UniProt P12931 Q2M4I4
RefSeq (mRNA) NM_005417 NM_001025395
RefSeq (protein) NP_005408 NP_001020566
Lokacija (UCSC) Chr 20:
35.41 - 35.47 Mb		 Chr 2:
157.12 - 157.16 Mb
PubMed pretraga
Затвори

Ovaj gen je sličan sa genom sarkoma virusa. Ovaj proto-onkogen može da igra ulogu u regulisanju embrionalnog razvoja i rasta ćelija. Proteinska kinaza koju ovaj gen kodira se može inhibirati fosforilacijom kinazom. Mutacije ovog gena mogu da učestvuju u malignom razvoju raka debelog creva. Dve transkriptne varijante koje kodiraju isti protein su nađene za ovaj gen.[2]

Za gen je bilo pokazano da interaguje sa ,[3][4] ,[5] ,[6] Jedreni translokator arilnog ugljovodoničnog receptora,[7] Aryl hydrocarbon receptor,[7] ,[8] ,[9][10] receptor ,[11][12] Androgenski receptor,[13][14][15] Proteinska kinaza Mζ,[16] ,[17] ,[8][18] Beta-3 adrenergički receptor,[19] Kinaza beta adrenergičkog receptora,[8] Receptor epidermalnog faktora rasta,[9][20][21] ,[22][23][24][25][26][27] ,[28] ,[29] Distroglikan,[30] Estrogenski receptor alfa,[13][31][32][33] Estrogenski receptor beta,[13][33] ,[34] ,[35][36][37][38][39] DDEF1,[40] ,[41][42] ,[20][43][44] ,[45][22][46][47][48][24] SHB,[49] ,[50] Faktor responsa seruma,[51] ,[52][53][54][55] Receptor retinoiske kiseline alfa,[32][56] Protein Viskot-Oldrić sindroma,[57][58] RICS,[59] proteinski activator 1,[60][61] [62] i .[63]

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    „Entrez Gene: SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)”.
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