Sibutramin

Sibutramin je organsko jedinjenje, koje sadrži 17 atoma ugljenika i ima molekulsku masu od 279,848 .^{[1][2][3][4][5][6]}

Klinički podaci
Prodajno ime
	Monografija
Način primene	Oralno
Farmakokinetički podaci
Poluvreme eliminacije	1,1 h
Identifikatori
	106650-56-0 Y
kod	()
	5210
	Y
	5021 Y
	Y
	1419 Y
Hemijski podaci
Formula	1726
Molarna masa	279,848
Y  Y
Fizički podaci
Tačka topljenja

Osobine

Osobina	Vrednost
Broj akceptora vodonika	1
Broj donora vodonika	0
Broj rotacionih veza	5
Particioni koeficijent[7] (	5,2
Rastvorljivost[8] ())	-5,6
Polarna površina[9] (, Å2)	3,2

Reference

1. Sharma, B.; Henderson, D. C. (август 2008). „Sibutramine: Current status as an anti-obesity drug and its future perspectives”. Expert Opinion on Pharmacotherapy. 9 (12): 2161—73. PMID 18671470. S2CID 71049588. doi:10.1517/14656566.9.12.2161.CS1 одржавање: Формат датума (веза)
2. Tziomalos, K.; Krassas, G. E.; Tzotzas, T. (2009). „The use of sibutramine in the management of obesity and related disorders: An update”. Vascular Health and Risk Management. 5 (1): 441—52. PMC 2686261 . PMID 19475780. doi:10.2147/vhrm.s4027.
3. Heal, D. J.; Aspley, S.; Prow, M. R.; Jackson, H. C.; Martin, K. F.; Cheetham, S. C. (1998). „Sibutramine: A novel anti-obesity drug. A review of the pharmacological evidence to differentiate it from d-amphetamine and d-fenfluramine”. International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity. 22 Suppl 1: S18—28; discussion S29. PMID 9758240.
4. Stock, M. J. (1997). „Sibutramine: A review of the pharmacology of a novel anti-obesity agent”. International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity. 21 Suppl 1: S25—9. PMID 9130038.
5.  уреди
6.  уреди
7. Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o.
8.  уреди
9.  уреди

Literatura

• Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
• Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.

Spoljašnje veze

Molimo Vas, obratite pažnju na važno upozorenje u vezi sa temama iz oblasti medicine (zdravlja).