Cefoperazon

Cefoperazon je organsko jedinjenje, koje sadrži 25 atoma ugljenika i ima molekulsku masu od 645,667 .^[1][2][3]

Klinički podaci
	Monografija
Način primene	Intramaskularno, intravenozno
Farmakokinetički podaci
Poluvreme eliminacije	2,0 h
Identifikatori
	62893-19-0 Y
kod	()
	44185
	Y
	40204 Y
	Y
	:3493 Y
	507674 Y
Hemijski podaci
Formula	2527982
Molarna masa	645,667
Y  Y
Fizički podaci
Tačka topljenja

Osobine

Osobina	Vrednost
Broj akceptora vodonika	13
Broj donora vodonika	4
Broj rotacionih veza	9
Particioni koeficijent[4] (	-0,8
Rastvorljivost[5] ())	-4,4
Polarna površina[6] (, Å2)	270,9

Reference

1. Jones, R. N.; Barry, A. L. (1983). „Cefoperazone: A review of its antimicrobial spectrum, beta-lactamase stability, enzyme inhibition, and other in vitro characteristics”. Reviews of Infectious Diseases. 5 (1): S108—26. PMID 6221381. doi:10.1093/clinids/5.supplement_1.s108.
2. Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: a comprehensive resource for 'omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.
3. Wishart, D. S.; Knox, C.; Guo, A. C.; Cheng, D.; Shrivastava, S.; Tzur, D.; Gautam, B.; Hassanali, M. (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.
4. Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o.
5. Tetko, I. V.; Tanchuk, V. Y.; Kasheva, T. N.; Villa, A. E. (2001). „Estimation of aqueous solubility of chemical compounds using E-state indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
6. Ertl, P.; Rohde, B.; Selzer, P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

Literatura

• Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
• Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.

Spoljašnje veze

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