Beta timozin

Beta timozini su familija proteina koji imaju zajedničku sekvencu od oko 40 aminokiselina. Oni su slični peptidu timozin β₄. Beta timozini su prisutni u skoro isključivo u multićelijskim životinjama. Timozin β₄ je originalno izdvojen iz grudne žlezde zajedno sa nekoliko drugih peptida, i oni su dobili zajedničko ime timozini. Kasnije je utvrđeno da su ti proteini strukturno i genetički različiti i da su prisutni u mnogim životinjskim tkivima.

Thumb — NMR struktura β-timozina. Timozin α₁^[1] i β-timozini su intrinsično nestrukturirani proteini, i.e. njima nedostaje stabilno savijanje kad su slobodni u vodenom rastvoru. Ova struktura, koja je uglavnom alfa heliks, je veštački stabilizovana organskim rastvaračem.^[2]

Reference

[1]
Grottesi A, Sette M, Palamara T, Rotilio G, Garaci E, Paci M (1998). „The conformation of peptide thymosin alpha 1 in solution and in a membrane-like environment by circular dichroism and NMR spectroscopy. A possible model for its interaction with the lymphocyte membrane”. Peptides. 19 (10): 1731—8. PMID 9880079. doi:10.1016/S0196-9781(98)00132-6.
[2]
: 1HJ0; Stoll R, Voelter W, Holak TA (1997). „Conformation of thymosin beta 9 in water/fluoroalcohol solution determined by NMR spectroscopy”. Biopolymers. 41 (6): 623—34. PMID 9108730. doi:10.1002/(SICI)1097-0282(199705)41:6<623::AID-BIP3>3.0.CO;2-S. „The thymosin is β9, bovine orthologue of human β10. Stabilised by organic solvent, the structure was determined by NMR. (Free β-thymosins lack a stable fold in solution)”

Vidi još

[1] [1]
Grottesi A, Sette M, Palamara T, Rotilio G, Garaci E, Paci M (1998). „The conformation of peptide thymosin alpha 1 in solution and in a membrane-like environment by circular dichroism and NMR spectroscopy. A possible model for its interaction with the lymphocyte membrane”. Peptides. 19 (10): 1731—8. PMID 9880079. doi:10.1016/S0196-9781(98)00132-6.

[1HJ0.pdb-2] [2]
: 1HJ0; Stoll R, Voelter W, Holak TA (1997). „Conformation of thymosin beta 9 in water/fluoroalcohol solution determined by NMR spectroscopy”. Biopolymers. 41 (6): 623—34. PMID 9108730. doi:10.1002/(SICI)1097-0282(199705)41:6<623::AID-BIP3>3.0.CO;2-S. „The thymosin is β9, bovine orthologue of human β10. Stabilised by organic solvent, the structure was determined by NMR. (Free β-thymosins lack a stable fold in solution)”

[1]

[2]