hypothesis is on the Academic Word List. Pronunciation IPA (key): /haɪˈpɒθɪsɪs/ Audio (US)(file) Noun Singular hypothesis Plural hypotheses Hypothesis is on the Academic Vocabulary List. (countable) A hypothesis is a guess about what will happen, usually in scientific experiments. We will test the hypothesis that the change will have no effect. The results of the experiment support the hypothesis. (uncountable) A guess with no evidence to support it. This idea is purely a hypothesis. It has not been proven Synonyms theory speculationWikiwand - on Seamless Wikipedia browsing. On steroids.