Bioorthogonal chemistry

The term bioorthogonal chemistry is about any chemical reaction that can happen inside of living systems without causing any problems with its native biochemical processes.^[1][2][3] The term was created by Carolyn Bertozzi in 2003.^[4][5] The idea of bioorthogonal reaction has caused a larger study of biomolecules such as glycans, proteins,^[6] and lipids.^[7]

References

1. Sletten, Ellen M.; Bertozzi, Carolyn R. (2009). "Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality". Angewandte Chemie International Edition. 48 (38): 6974–98. doi:10.1002/anie.200900942. PMC 2864149. PMID 19714693.
2. Prescher, Jennifer A.; Dube, Danielle H.; Bertozzi, Carolyn R. (2004). "Chemical remodelling of cell surfaces in living animals". Nature. 430 (7002): 873–7. Bibcode:2004Natur.430..873P. doi:10.1038/nature02791. PMID 15318217. S2CID 4371934.
3. Prescher, Jennifer A; Bertozzi, Carolyn R (2005). "Chemistry in living systems". Nature Chemical Biology. 1 (1): 13–21. doi:10.1038/nchembio0605-13. PMID 16407987. S2CID 40548615.
4. Hang, Howard C.; Yu, Chong; Kato, Darryl L.; Bertozzi, Carolyn R. (2003-12-09). "A metabolic labeling approach toward proteomic analysis of mucin-type O-linked glycosylation". Proceedings of the National Academy of Sciences. 100 (25): 14846–14851. Bibcode:2003PNAS..10014846H. doi:10.1073/pnas.2335201100. ISSN 0027-8424. PMC 299823. PMID 14657396.
5. Sletten, Ellen M.; Bertozzi, Carolyn R. (2011). "From Mechanism to Mouse: A Tale of Two Bioorthogonal Reactions". Accounts of Chemical Research. 44 (9): 666–676. doi:10.1021/ar200148z. PMC 3184615. PMID 21838330.
6. Plass, Tilman; Milles, Sigrid; Koehler, Christine; Schultz, Carsten; Lemke, Edward A. (2011). "Genetically Encoded Copper-Free Click Chemistry". Angewandte Chemie International Edition. 50 (17): 3878–3881. doi:10.1002/anie.201008178. PMC 3210829. PMID 21433234.
7. Neef, Anne B.; Schultz, Carsten (2009). "Selective Fluorescence Labeling of Lipids in Living Cells". Angewandte Chemie International Edition. 48 (8): 1498–500. doi:10.1002/anie.200805507. PMID 19145623.