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Ramelteon
chemical compound / From Wikipedia, the free encyclopedia
Ramelteon is a central nervous system (CNS) depressant medication that can help people sleep. It is used for patients that have trouble falling asleep.
Ramelteon has significant drug-drug interaction with the following drugs: amiodarone[*], ciprofloxacin[*], fluvoxamine[*], ticlopidine[*].
Quick Facts Clinical data, Trade names ...
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Clinical data | |
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Trade names | Rozerem, others |
Synonyms | TAK-375 |
AHFS/Drugs.com | Monograph |
MedlinePlus | a605038 |
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Dependence liability | Low[1] |
Routes of administration | By mouth |
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Pharmacokinetic data | |
Bioavailability | 1.8%[3] |
Protein binding | 82% (mainly albumin)[3] |
Metabolism | Liver (CYP1A2 major, CYP2C and CYP3A4 minor)[3] |
Metabolites | M-II (active metabolite)[3] |
Elimination half-life | Ramelteon: 1–2.6 hours[3] M-II: 2–5 hours[3][4] |
Excretion | Kidney: 84%[3] Feces: 4%[3] |
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ECHA InfoCard | 100.215.666 ![]() |
Chemical and physical data | |
Formula | C16H21NO2 |
Molar mass | 259.35 g·mol−1 |
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