chemical compound From Wikipedia, the free encyclopedia
Chlorpromazine, also known by its trade name Thorazine, is an antipsychotic drug. It is typically used to treat Schizophrenia. It has also been used to treat bipolar disorder. It has been shown to help uncontrollable hiccups disappear. It is also used to help with nausea and vomiting.[2] Chlorpromazine was developed in 1950, making it the oldest antipsychotic drug.[3]
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Trade names | Largactil, Thorazine, many others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a682040 |
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Routes of administration | Oral (tablets and syrup available), rectal, IM, IV infusion |
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Bioavailability | 10–80% (Oral; large interindividual variation)[1] |
Protein binding | 90–99%[1] |
Metabolism | Liver, mostly CYP2D6-mediated[1] |
Elimination half-life | 30 hours |
Excretion | Urine (43–65% in 24 hrs)[1] |
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ECHA InfoCard | 100.000.042 |
Chemical and physical data | |
Formula | C17H19ClN2S |
Molar mass | 318.86 g/mol (free base) 355.33 g/mol (hydrochloride) |
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