Tiazid

Tiazid je tip molekula^[1] i klasa diuretika^[2] koji se često koriste za tretiranje hipertenzije (visokog krvnog pristiska) i edema (poput onih uzrokovanih bolestima srca, jetre, ili bubrega).

Benzotiadiazin

Hlorotiazid

Hidrohlorotiazid

Tiazidi i tiazidima slični diuretici redukuju rizik od smrti, šloga, srčanog udara i zatajenja srca usled hipertenzije.^[3] U većini zemalja, tiazidi su najjeftiniji antihipertenzivni lekovi.^[4]

Reference

1. MeSH Thiazides
2. MeSH Thiazide+Diuretics
3. Wright JM, Musini VM (July 2009). Wright, James M. ur. „First-line drugs for hypertension”. Cochrane Database Syst Rev 8 (3): CD001841. DOI:10.1002/14651858.CD001841.pub2. PMID 19588327.
4. Whitworth JA, World Health Organization, International Society of Hypertension Writing Group (November 2003). „2003 World Health Organization (WHO)/International Society of Hypertension (ISH) statement on management of hypertension”. J Hypertens 21 (11): 1983–92. DOI:10.1097/00004872-200311000-00002. PMID 14597836.

Literatura

• Bertram G. Katzung: Basic and Clinical Pharmacology. Kapitel 15 Diuretic agents. Mcgraw-Hill Professional. 9th Edition, 2004, ISBN 978-0-07-141092-2
• Donald W. Seldin (Hrsgb.), Gerhard Giebisch (Hrsgb.): Diuretic Agents: Clinical Physiology and Pharmacology. Kapitel 3 A history of diuretics, S. 3 ff. und Kapitel Academic Press. 1st edition, 1997, ISBN 978-0-12-635690-8
• Craig, Stitzel: Modern Pharmacology with Clinical Applications. Kapitel 21 Diuretic Drugs, S. 249 ff. Lippincott Raven, 6th Edition, 2003, ISBN 978-0-7817-3762-3

Vanjske veze