Receptor retinoinske kiseline alfa

Receptor retinoinske kiseline, alfa
	; PDB slika je bazirana na 1dkf.
Dostupne strukture
	1dkf, 1dsz, 1hra
Identifikatori
Simboli	RARA; NR1B1; RAR
Vanjski ID	OMIM: 180240 MGI: 97856 HomoloGene: 20262 GeneCards: RARA Gene
Ontologija gena
Molekularna funkcija	• aktivnost transkripcionog faktora; • aktivnost steroidnog hormonskog receptora; • aktivnost receptora retinoinske kiseline; • aktivnost transkripcionog koaktivatora; • vezivanje za proteine; • vezivanje cink jona; • sekvenca-specifično DNK vezivanje; • vezivanje metalnih jona;
Celularna komponenta	• nukleus;
Biološki proces	• transkripcija; • regulacija transkripcije, DNK-zavisna; • prenos signala;
Pregled RNK izražavanja
	podaci
Ortolozi

Receptor retinoinske kiseline alfa (RAR-alfa), isto poznat kao NR1B1 (nuklearni receptor potfamilije 1, grupa B, član 1), je nuklearni receptor kodiran genom RARA.

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Kratke činjenice Dostupne strukture, Identifikatori ...

Zatvori

Pokazano je za receptor retinoinske kiseline gama da može da formnira interakciju sa NCOA6,^[1]^[2]^[3] CLOCK,^[4] TADA3L,^[5] Cink prst i BTB domen-sadržavajući protein 16,^[6] Src,^[7]^[8] Nuklearni receptor srodni 1 protein (NURR1),^[9] Mali heterodimer partner (SHP),^[10]^[11] NPAS2,^[4] Cyclin D3,^[12] Nuklearni receptor korepresor 1,^[13]^[14] BAG1,^[15] Nuklearni receptor korepresor 2,^[16]^[17] NRIP1,^[18]^[19]^[20] Protein promielocitna leukemije^[21] i Retinoidni X receptor alfa.^[22]^[23]

[1]
Lee, S K; Jung S Y, Kim Y S, Na S Y, Lee Y C, Lee J W (Feb 2001). „Two distinct nuclear receptor-interaction domains and CREB-binding protein-dependent transactivation function of activating signal cointegrator-2”. Mol. Endocrinol. (United States) 15 (2): 241–54. ISSN 0888-8809. PMID 11158331.
[2]
Lee, S K; Anzick S L, Choi J E, Bubendorf L, Guan X Y, Jung Y K, Kallioniemi O P, Kononen J, Trent J M, Azorsa D, Jhun B H, Cheong J H, Lee Y C, Meltzer P S, Lee J W (Nov 1999). „A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo”. J. Biol. Chem. (UNITED STATES) 274 (48): 34283–93. ISSN 0021-9258. PMID 10567404.
[3]
Ko, L; Cardona G R, Chin W W (May 2000). „Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator”. Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (11): 6212–7. ISSN 0027-8424. PMID 10823961.
[4]
McNamara, P; Seo S B, Rudic R D, Sehgal A, Chakravarti D, FitzGerald G A (Jun 2001). „Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: a humoral mechanism to reset a peripheral clock”. Cell (United States) 105 (7): 877–89. ISSN 0092-8674. PMID 11439184.
[5]
Zeng, Musheng; Kumar Ajay, Meng Gaoyuan, Gao Qingshen, Dimri Goberdhan, Wazer David, Band Hamid, Band Vimla (Nov 2002). „Human papilloma virus 16 E6 oncoprotein inhibits retinoic X receptor-mediated transactivation by targeting human ADA3 coactivator”. J. Biol. Chem. (United States) 277 (47): 45611–8. DOI:10.1074/jbc.M208447200. ISSN 0021-9258. PMID 12235159.
[6]
Martin; Delmotte , Formstecher , Lefebvre (Sep 2003). „PLZF is a negative regulator of retinoic acid receptor transcriptional activity”. Nucl. Recept. 1 (1): 6. DOI:10.1186/1478-1336-1-6. PMID 14521715.
[7]
Kim, H J; Yi J Y, Sung H S, Moore D D, Jhun B H, Lee Y C, Lee J W (Sep 1999). „Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation”. Mol. Cell. Biol. (UNITED STATES) 19 (9): 6323–32. ISSN 0270-7306. PMID 10454579.
[8]
He, Bin; Wilson Elizabeth M (Mar 2003). „Electrostatic modulation in steroid receptor recruitment of LXXLL and FXXLF motifs”. Mol. Cell. Biol. (United States) 23 (6): 2135–50. ISSN 0270-7306. PMID 12612084.
[9]
Perlmann, T; Jansson L (Apr 1995). „A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1”. Genes Dev. (UNITED STATES) 9 (7): 769–82. ISSN 0890-9369. PMID 7705655.
[10]
Seol, W; Choi H S, Moore D D (May 1996). „An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors”. Science (UNITED STATES) 272 (5266): 1336–9. ISSN 0036-8075. PMID 8650544.
[11]
Seol, W; Hanstein B, Brown M, Moore D D (Oct 1998). „Inhibition of estrogen receptor action by the orphan receptor SHP (short heterodimer partner)”. Mol. Endocrinol. (UNITED STATES) 12 (10): 1551–7. ISSN 0888-8809. PMID 9773978.
[12]
Despouy, Gilles; Bastie Jean-Nöel, Deshaies Sylvie, Balitrand Nicole, Mazharian Alexandra, Rochette-Egly Cécile, Chomienne Christine, Delva Laurent (Feb 2003). „Cyclin D3 is a cofactor of retinoic acid receptors, modulating their activity in the presence of cellular retinoic acid-binding protein II”. J. Biol. Chem. (United States) 278 (8): 6355–62. DOI:10.1074/jbc.M210697200. ISSN 0021-9258. PMID 12482873.
[13]
Dowell, P; Ishmael J E, Avram D, Peterson V J, Nevrivy D J, Leid M (May 1999). „Identification of nuclear receptor corepressor as a peroxisome proliferator-activated receptor alpha interacting protein”. J. Biol. Chem. (UNITED STATES) 274 (22): 15901–7. ISSN 0021-9258. PMID 10336495.
[14]
Guidez, F; Ivins S, Zhu J, Söderström M, Waxman S, Zelent A (Apr 1998). „Reduced retinoic acid-sensitivities of nuclear receptor corepressor binding to PML- and PLZF-RARalpha underlie molecular pathogenesis and treatment of acute promyelocytic leukemia”. Blood (UNITED STATES) 91 (8): 2634–42. ISSN 0006-4971. PMID 9531570.
[15]
Liu, R; Takayama S, Zheng Y, Froesch B, Chen G Q, Zhang X, Reed J C, Zhang X K (Jul 1998). „Interaction of BAG-1 with retinoic acid receptor and its inhibition of retinoic acid-induced apoptosis in cancer cells”. J. Biol. Chem. (UNITED STATES) 273 (27): 16985–92. ISSN 0021-9258. PMID 9642262.
[16]
Dong, Shuo; Tweardy David J (Apr 2002). „Interactions of STAT5b-RARalpha, a novel acute promyelocytic leukemia fusion protein, with retinoic acid receptor and STAT3 signaling pathways”. Blood (United States) 99 (8): 2637–46. ISSN 0006-4971. PMID 11929748.
[17]
Hong, S H; David G, Wong C W, Dejean A, Privalsky M L (Aug 1997). „SMRT corepressor interacts with PLZF and with the PML-retinoic acid receptor alpha (RARalpha) and PLZF-RARalpha oncoproteins associated with acute promyelocytic leukemia”. Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 94 (17): 9028–33. ISSN 0027-8424. PMID 9256429.
[18]
Hu, Xinli; Chen Yixin, Farooqui Mariya, Thomas Mary C, Chiang Cheng-Ming, Wei Li-Na (Jan 2004). „Suppressive effect of receptor-interacting protein 140 on coregulator binding to retinoic acid receptor complexes, histone-modifying enzyme activity, and gene activation”. J. Biol. Chem. (United States) 279 (1): 319–25. DOI:10.1074/jbc.M307621200. ISSN 0021-9258. PMID 14581481.
[19]
Farooqui, Mariya; Franco Peter J, Thompson Jim, Kagechika Hiroyuki, Chandraratna Roshantha A S, Banaszak Len, Wei Li-Na (Feb 2003). „Effects of retinoid ligands on RIP140: molecular interaction with retinoid receptors and biological activity”. Biochemistry (United States) 42 (4): 971–9. DOI:10.1021/bi020497k. ISSN 0006-2960. PMID 12549917.
[20]
L'Horset, F; Dauvois S, Heery D M, Cavaillès V, Parker M G (Nov 1996). „RIP-140 interacts with multiple nuclear receptors by means of two distinct sites”. Mol. Cell. Biol. (UNITED STATES) 16 (11): 6029–36. ISSN 0270-7306. PMID 8887632.
[21]
Zhong, S; Delva L, Rachez C, Cenciarelli C, Gandini D, Zhang H, Kalantry S, Freedman L P, Pandolfi P P (Nov 1999). „A RA-dependent, tumour-growth suppressive transcription complex is the target of the PML-RARalpha and T18 oncoproteins”. Nat. Genet. (UNITED STATES) 23 (3): 287–95. DOI:10.1038/15463. ISSN 1061-4036. PMID 10610177.
[22]
Benkoussa, Madjid; Brand Céline, Delmotte Marie-Hélène, Formstecher Pierre, Lefebvre Philippe (Jul 2002). „Retinoic acid receptors inhibit AP1 activation by regulating extracellular signal-regulated kinase and CBP recruitment to an AP1-responsive promoter”. Mol. Cell. Biol. (United States) 22 (13): 4522–34. ISSN 0270-7306. PMID 12052862.
[23]
Bugge, T H; Pohl J, Lonnoy O, Stunnenberg H G (Apr 1992). „RXR alpha, a promiscuous partner of retinoic acid and thyroid hormone receptors”. EMBO J. (ENGLAND) 11 (4): 1409–18. ISSN 0261-4189. PMID 1314167.

Receptor retinoinske kiseline
Akutna promijelocitna leukemija

[pmid11158331-1] [1]
Lee, S K; Jung S Y, Kim Y S, Na S Y, Lee Y C, Lee J W (Feb 2001). „Two distinct nuclear receptor-interaction domains and CREB-binding protein-dependent transactivation function of activating signal cointegrator-2”. Mol. Endocrinol. (United States) 15 (2): 241–54. ISSN 0888-8809. PMID 11158331.

[pmid10567404-2] [2]
Lee, S K; Anzick S L, Choi J E, Bubendorf L, Guan X Y, Jung Y K, Kallioniemi O P, Kononen J, Trent J M, Azorsa D, Jhun B H, Cheong J H, Lee Y C, Meltzer P S, Lee J W (Nov 1999). „A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo”. J. Biol. Chem. (UNITED STATES) 274 (48): 34283–93. ISSN 0021-9258. PMID 10567404.

[pmid10823961-3] [3]
Ko, L; Cardona G R, Chin W W (May 2000). „Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator”. Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (11): 6212–7. ISSN 0027-8424. PMID 10823961.

[pmid11439184-4] [4]
McNamara, P; Seo S B, Rudic R D, Sehgal A, Chakravarti D, FitzGerald G A (Jun 2001). „Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: a humoral mechanism to reset a peripheral clock”. Cell (United States) 105 (7): 877–89. ISSN 0092-8674. PMID 11439184.

[pmid12235159-5] [5]
Zeng, Musheng; Kumar Ajay, Meng Gaoyuan, Gao Qingshen, Dimri Goberdhan, Wazer David, Band Hamid, Band Vimla (Nov 2002). „Human papilloma virus 16 E6 oncoprotein inhibits retinoic X receptor-mediated transactivation by targeting human ADA3 coactivator”. J. Biol. Chem. (United States) 277 (47): 45611–8. DOI:10.1074/jbc.M208447200. ISSN 0021-9258. PMID 12235159.

[pmid14521715-6] [6]
Martin; Delmotte , Formstecher , Lefebvre (Sep 2003). „PLZF is a negative regulator of retinoic acid receptor transcriptional activity”. Nucl. Recept. 1 (1): 6. DOI:10.1186/1478-1336-1-6. PMID 14521715.

[pmid10454579-7] [7]
Kim, H J; Yi J Y, Sung H S, Moore D D, Jhun B H, Lee Y C, Lee J W (Sep 1999). „Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation”. Mol. Cell. Biol. (UNITED STATES) 19 (9): 6323–32. ISSN 0270-7306. PMID 10454579.

[pmid12612084-8] [8]
He, Bin; Wilson Elizabeth M (Mar 2003). „Electrostatic modulation in steroid receptor recruitment of LXXLL and FXXLF motifs”. Mol. Cell. Biol. (United States) 23 (6): 2135–50. ISSN 0270-7306. PMID 12612084.

[pmid7705655-9] [9]
Perlmann, T; Jansson L (Apr 1995). „A novel pathway for vitamin A signaling mediated by RXR heterodimerization with NGFI-B and NURR1”. Genes Dev. (UNITED STATES) 9 (7): 769–82. ISSN 0890-9369. PMID 7705655.

[pmid8650544-10] [10]
Seol, W; Choi H S, Moore D D (May 1996). „An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors”. Science (UNITED STATES) 272 (5266): 1336–9. ISSN 0036-8075. PMID 8650544.

[pmid9773978-11] [11]
Seol, W; Hanstein B, Brown M, Moore D D (Oct 1998). „Inhibition of estrogen receptor action by the orphan receptor SHP (short heterodimer partner)”. Mol. Endocrinol. (UNITED STATES) 12 (10): 1551–7. ISSN 0888-8809. PMID 9773978.

[pmid12482873-12] [12]
Despouy, Gilles; Bastie Jean-Nöel, Deshaies Sylvie, Balitrand Nicole, Mazharian Alexandra, Rochette-Egly Cécile, Chomienne Christine, Delva Laurent (Feb 2003). „Cyclin D3 is a cofactor of retinoic acid receptors, modulating their activity in the presence of cellular retinoic acid-binding protein II”. J. Biol. Chem. (United States) 278 (8): 6355–62. DOI:10.1074/jbc.M210697200. ISSN 0021-9258. PMID 12482873.

[pmid10336495-13] [13]
Dowell, P; Ishmael J E, Avram D, Peterson V J, Nevrivy D J, Leid M (May 1999). „Identification of nuclear receptor corepressor as a peroxisome proliferator-activated receptor alpha interacting protein”. J. Biol. Chem. (UNITED STATES) 274 (22): 15901–7. ISSN 0021-9258. PMID 10336495.

[pmid9531570-14] [14]
Guidez, F; Ivins S, Zhu J, Söderström M, Waxman S, Zelent A (Apr 1998). „Reduced retinoic acid-sensitivities of nuclear receptor corepressor binding to PML- and PLZF-RARalpha underlie molecular pathogenesis and treatment of acute promyelocytic leukemia”. Blood (UNITED STATES) 91 (8): 2634–42. ISSN 0006-4971. PMID 9531570.

[pmid9642262-15] [15]
Liu, R; Takayama S, Zheng Y, Froesch B, Chen G Q, Zhang X, Reed J C, Zhang X K (Jul 1998). „Interaction of BAG-1 with retinoic acid receptor and its inhibition of retinoic acid-induced apoptosis in cancer cells”. J. Biol. Chem. (UNITED STATES) 273 (27): 16985–92. ISSN 0021-9258. PMID 9642262.

[pmid11929748-16] [16]
Dong, Shuo; Tweardy David J (Apr 2002). „Interactions of STAT5b-RARalpha, a novel acute promyelocytic leukemia fusion protein, with retinoic acid receptor and STAT3 signaling pathways”. Blood (United States) 99 (8): 2637–46. ISSN 0006-4971. PMID 11929748.

[pmid9256429-17] [17]
Hong, S H; David G, Wong C W, Dejean A, Privalsky M L (Aug 1997). „SMRT corepressor interacts with PLZF and with the PML-retinoic acid receptor alpha (RARalpha) and PLZF-RARalpha oncoproteins associated with acute promyelocytic leukemia”. Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 94 (17): 9028–33. ISSN 0027-8424. PMID 9256429.

[pmid14581481-18] [18]
Hu, Xinli; Chen Yixin, Farooqui Mariya, Thomas Mary C, Chiang Cheng-Ming, Wei Li-Na (Jan 2004). „Suppressive effect of receptor-interacting protein 140 on coregulator binding to retinoic acid receptor complexes, histone-modifying enzyme activity, and gene activation”. J. Biol. Chem. (United States) 279 (1): 319–25. DOI:10.1074/jbc.M307621200. ISSN 0021-9258. PMID 14581481.

[pmid12549917-19] [19]
Farooqui, Mariya; Franco Peter J, Thompson Jim, Kagechika Hiroyuki, Chandraratna Roshantha A S, Banaszak Len, Wei Li-Na (Feb 2003). „Effects of retinoid ligands on RIP140: molecular interaction with retinoid receptors and biological activity”. Biochemistry (United States) 42 (4): 971–9. DOI:10.1021/bi020497k. ISSN 0006-2960. PMID 12549917.

[pmid8887632-20] [20]
L'Horset, F; Dauvois S, Heery D M, Cavaillès V, Parker M G (Nov 1996). „RIP-140 interacts with multiple nuclear receptors by means of two distinct sites”. Mol. Cell. Biol. (UNITED STATES) 16 (11): 6029–36. ISSN 0270-7306. PMID 8887632.

[pmid10610177-21] [21]
Zhong, S; Delva L, Rachez C, Cenciarelli C, Gandini D, Zhang H, Kalantry S, Freedman L P, Pandolfi P P (Nov 1999). „A RA-dependent, tumour-growth suppressive transcription complex is the target of the PML-RARalpha and T18 oncoproteins”. Nat. Genet. (UNITED STATES) 23 (3): 287–95. DOI:10.1038/15463. ISSN 1061-4036. PMID 10610177.

[pmid12052862-22] [22]
Benkoussa, Madjid; Brand Céline, Delmotte Marie-Hélène, Formstecher Pierre, Lefebvre Philippe (Jul 2002). „Retinoic acid receptors inhibit AP1 activation by regulating extracellular signal-regulated kinase and CBP recruitment to an AP1-responsive promoter”. Mol. Cell. Biol. (United States) 22 (13): 4522–34. ISSN 0270-7306. PMID 12052862.

[pmid1314167-23] [23]
Bugge, T H; Pohl J, Lonnoy O, Stunnenberg H G (Apr 1992). „RXR alpha, a promiscuous partner of retinoic acid and thyroid hormone receptors”. EMBO J. (ENGLAND) 11 (4): 1409–18. ISSN 0261-4189. PMID 1314167.

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Receptor retinoinske kiseline alfa

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Reference

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