RAR-srodni orfan receptor alfa

RAR-srodni orfan receptor alfa (ROR-alfa), ili NR1F1 (nuklearni receptor potfamilije 1, grupe F, član 1) je nuklearni receptor kodiran genom RORA.

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RAR-vezani orfan receptor A
PDB slika bazirana na 1n83..
Dostupne strukture
1n83, 1s0x
Identifikatori
Simboli	RORA; ROR1; ROR2; MGC119326; MGC119329; NR1F1; ROR3; RZRA
Vanjski ID	OMIM: 600825 MGI: 104661 HomoloGene: 56594 GeneCards: RORA Gene
Ontologija gena Molekularna funkcija • aktivnost transkripcinog faktora • aktivnost steroidnog hormonskog receptora • vezivanje proteina • vezivanje jona cinka • sekvenca-specifično DNK vezivanje • vezivanje metalnih jona Celularna komponenta • nukleus Biološki proces • transkripcija • regulacija transkripcije, DNK-zavisna • biosintetički proces azot-oksida • prenos signala • regulacija aktivnosti makrofaga • cGMP metabolički proces
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta	Čovek	Miš
Entrez	6095	19883
Ensembl	ENSG00000069667	ENSMUSG00000032238
UniProt	P35398	Q3U1P4
RefSeq (mRNA)	NM_002943	XM_903197
RefSeq (protein)	NP_002934	XP_908290
Lokacija (UCSC)	Chr 15: 58.58 - 59.31 Mb	Chr 9: 68.45 - 69.18 Mb
PubMed pretraga

Protein kodiran ovim genom je član NR1 potfamilije nuklearnih hormonskih receptora. On može biti vezan kao monomer ili homodimer za elemente hormonskog odgovora uzvodno od nekoliko gena da bi pojačao ekspresiju tih gena. Specifične funkcije ovog proteina su nepoznate, ali je bilo pokazano da ima interakciju sa NM23-2, nukleozid difosfat kinazom koja učestvuje u organogenezi i diferencijaciji, kao i sa NM23-1, produktom tumor metastaznog supresor kandidatnog gena. Četiri transkriptne varijante koje kodiraju različite izoforme su bile opisane za ovaj gen.^[1]

Interakcije

Za RAR-srodni orfan receptor alfa je pokazano da uspostavlja interakciju sa EP300^[2] i NME1.^[3]

Reference

1. „Entrez Gene: RORA RAR-related orphan receptor A”.
2. Lau, P; Bailey P, Dowhan D H, Muscat G E (Jan 1999). „Exogenous expression of a dominant negative RORalpha1 vector in muscle cells impairs differentiation: RORalpha1 directly interacts with p300 and myoD”. Nucleic Acids Res. (ENGLAND) 27 (2): 411–20. ISSN 0305-1048. PMID 9862959.
3. Paravicini, G; Steinmayr M, André E, Becker-André M (Oct 1996). „The metastasis suppressor candidate nucleotide diphosphate kinase NM23 specifically interacts with members of the ROR/RZR nuclear orphan receptor subfamily”. Biochem. Biophys. Res. Commun. (UNITED STATES) 227 (1): 82–7. DOI:10.1006/bbrc.1996.1471. ISSN 0006-291X. PMID 8858107.

Literatura

• Giguère V, Beatty B, Squire J, et al. (1996). „The orphan nuclear receptor ROR alpha (RORA) maps to a conserved region of homology on human chromosome 15q21-q22 and mouse chromosome 9.”. Genomics 28 (3): 596–8. DOI:10.1006/geno.1995.1197. PMID 7490103.
• Steinhilber D, Brungs M, Werz O, et al. (1995). „The nuclear receptor for melatonin represses 5-lipoxygenase gene expression in human B lymphocytes.”. J. Biol. Chem. 270 (13): 7037–40. DOI:10.1074/jbc.270.13.7037. PMID 7706239.
• Forman BM, Chen J, Blumberg B, et al. (1995). „Cross-talk among ROR alpha 1 and the Rev-erb family of orphan nuclear receptors.”. Mol. Endocrinol. 8 (9): 1253–61. DOI:10.1210/me.8.9.1253. PMID 7838158.
• Becker-André M, André E, DeLamarter JF (1993). „Identification of nuclear receptor mRNAs by RT-PCR amplification of conserved zinc-finger motif sequences.”. Biochem. Biophys. Res. Commun. 194 (3): 1371–9. DOI:10.1006/bbrc.1993.1976. PMID 7916608.
• Giguère V, Tini M, Flock G, et al. (1994). „Isoform-specific amino-terminal domains dictate DNA-binding properties of ROR alpha, a novel family of orphan hormone nuclear receptors.”. Genes Dev. 8 (5): 538–53. DOI:10.1101/gad.8.5.538. PMID 7926749.
• Carlberg C, Hooft van Huijsduijnen R, Staple JK, et al. (1994). „RZRs, a new family of retinoid-related orphan receptors that function as both monomers and homodimers.”. Mol. Endocrinol. 8 (6): 757–70. DOI:10.1210/me.8.6.757. PMID 7935491.
• Paravicini G, Steinmayr M, André E, Becker-André M (1996). „The metastasis suppressor candidate nucleotide diphosphate kinase NM23 specifically interacts with members of the ROR/RZR nuclear orphan receptor subfamily.”. Biochem. Biophys. Res. Commun. 227 (1): 82–7. DOI:10.1006/bbrc.1996.1471. PMID 8858107.
• Lau P, Bailey P, Dowhan DH, Muscat GE (1999). „Exogenous expression of a dominant negative RORalpha1 vector in muscle cells impairs differentiation: RORalpha1 directly interacts with p300 and myoD.”. Nucleic Acids Res. 27 (2): 411–20. DOI:10.1093/nar/27.2.411. PMID 9862959.
• Atkins GB, Hu X, Guenther MG, et al. (1999). „Coactivators for the orphan nuclear receptor RORalpha.”. Mol. Endocrinol. 13 (9): 1550–7. DOI:10.1210/me.13.9.1550. PMID 10478845.
• Meyer T, Kneissel M, Mariani J, Fournier B (2000). „In vitro and in vivo evidence for orphan nuclear receptor RORalpha function in bone metabolism.”. Proc. Natl. Acad. Sci. U.S.A. 97 (16): 9197–202. DOI:10.1073/pnas.150246097. PMID 10900268.
• Gawlas K, Stunnenberg HG (2001). „Differential binding and transcriptional behaviour of two highly related orphan receptors, ROR alpha(4) and ROR beta(1).”. Biochim. Biophys. Acta 1494 (3): 236–41. PMID 11121580.
• Delerive P, Chin WW, Suen CS (2002). „Identification of Reverb(alpha) as a novel ROR(alpha) target gene.”. J. Biol. Chem. 277 (38): 35013–8. DOI:10.1074/jbc.M202979200. PMID 12114512.
• Moretti RM, Marelli MM, Motta M, Limonta P (2003). „Role of the orphan nuclear receptor ROR alpha in the control of the metastatic behavior of androgen-independent prostate cancer cells.”. Oncol. Rep. 9 (5): 1139–43. PMID 12168086.
• Raspè E, Mautino G, Duval C, et al. (2003). „Transcriptional regulation of human Rev-erbalpha gene expression by the orphan nuclear receptor retinoic acid-related orphan receptor alpha.”. J. Biol. Chem. 277 (51): 49275–81. DOI:10.1074/jbc.M206215200. PMID 12377782.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMID 12477932.
• Kallen J, Schlaeppi JM, Bitsch F, et al. (2004). „Crystal structure of the human RORalpha Ligand binding domain in complex with cholesterol sulfate at 2.2 A.”. J. Biol. Chem. 279 (14): 14033–8. DOI:10.1074/jbc.M400302200. PMID 14722075.
• Migita H, Satozawa N, Lin JH, et al. (2004). „RORalpha1 and RORalpha4 suppress TNF-alpha-induced VCAM-1 and ICAM-1 expression in human endothelial cells.”. FEBS Lett. 557 (1-3): 269–74. DOI:10.1016/S0014-5793(03)01502-3. PMID 14741380.
• Miki N, Ikuta M, Matsui T (2004). „Hypoxia-induced activation of the retinoic acid receptor-related orphan receptor alpha4 gene by an interaction between hypoxia-inducible factor-1 and Sp1.”. J. Biol. Chem. 279 (15): 15025–31. DOI:10.1074/jbc.M313186200. PMID 14742449.
• Migita H, Morser J, Kawai K (2004). „Rev-erbalpha upregulates NF-kappaB-responsive genes in vascular smooth muscle cells.”. FEBS Lett. 561 (1-3): 69–74. DOI:10.1016/S0014-5793(04)00118-8. PMID 15013753.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMID 15489334.

Povezano

• RAR-srodni orfan receptor

Vanjske veze

• MeSH orphan+nuclear+receptor+ROR-gamma