Prolaktinski receptor

Prolaktinski receptor
Identifikatori
Simbol	PRLR
Entrez	5618
HUGO	9446
OMIM	176761
PDB	1RW5
RefSeq	NM_000949
UniProt	P16471
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Lokus	Hromozom 5 p13-p12

Prolaktinski receptor je kodiran genom na hromozomu 5p13-14. On je transmembranski receptor koji formira interakcije sa molekulom prolaktina.

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Zatvori

Ovaj receptor sadrži ekstracelularni region za koji se vezuje prolaktin, transmembranski region, i citoplasmatični region. Prolaktinski receptor je citokinski receptor.^[1] On je deo kaskade sekundarnih glasnika koja obuhvata JAK-STAT put, JAK-RUSH put,^[2]^[3] Ras-Raf-MAPK, i PI-3K.^[4]

Postoje varijacije između prolaktinskih receptora izraženih u različitim tkivima.^[5]

[1]
Prolactin: The multi-faceted potentiator of mammary growth and function. Trott JF, Schennink A, Petrie WK, Manjarin R, Vanklompenberg MK, Hovey RC. J Anim Sci. 2011 Dec 28.
[2]
Prolactin-induced Jak2 phosphorylation of RUSH: a key element in Jak/RUSH signaling. Helmer RA, Panchoo M, Dertien JS, Bhakta SM, Hewetson A, Chilton BS. Mol Cell Endocrinol. 2010 Aug 30;325(1-2):143-9.
[3]
Prolactin induces Jak2 phosphorylation of RUSHY195. Helmer RA, Dertien JS, Chilton BS. Mol Cell Endocrinol. 2011 May 16;338(1-2):79-83.
[4]
The role of prolactin in mammary carcinoma. Clevenger CV, Furth PA, Hankinson SE, Schuler LA. Endocr Rev. 2003 Feb;24(1):1-27.
[5]
Impact of prolactin receptor isoforms on reproduction. Binart N, Bachelot A, Bouilly J. Trends Endocrinol Metab. 2010 Jun;21(6):362-8.

MeSH Prolactin+receptor

[1] [1]
Prolactin: The multi-faceted potentiator of mammary growth and function. Trott JF, Schennink A, Petrie WK, Manjarin R, Vanklompenberg MK, Hovey RC. J Anim Sci. 2011 Dec 28.

[2] [2]
Prolactin-induced Jak2 phosphorylation of RUSH: a key element in Jak/RUSH signaling. Helmer RA, Panchoo M, Dertien JS, Bhakta SM, Hewetson A, Chilton BS. Mol Cell Endocrinol. 2010 Aug 30;325(1-2):143-9.

[3] [3]
Prolactin induces Jak2 phosphorylation of RUSHY195. Helmer RA, Dertien JS, Chilton BS. Mol Cell Endocrinol. 2011 May 16;338(1-2):79-83.

[4] [4]
The role of prolactin in mammary carcinoma. Clevenger CV, Furth PA, Hankinson SE, Schuler LA. Endocr Rev. 2003 Feb;24(1):1-27.

[5] [5]
Impact of prolactin receptor isoforms on reproduction. Binart N, Bachelot A, Bouilly J. Trends Endocrinol Metab. 2010 Jun;21(6):362-8.

[1]

[2]

[3]

[4]

[5]

Prolaktinski receptor

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Prolaktinski receptor

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Reference

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