PRX-07034

PRX-07034 je selektivni antagonist 5-HT₆ receptora.^[3] On utiče na kogniciju, poboljšava memoriju, i potencijalno umanjuje unos hrane i telesnu težinu kod glodara.^[3][4][5][6]

PRX-07034

(IUPAC) ime
N-[1-(5-hloro-2,3-dimetoksifenil)etil]-2-metilsulfonil-5-piperazin-1-ilanilin
Klinički podaci
Identifikatori
ATC kod	nije dodeljen
PubChem[1][2]	11532574
Hemijski podaci
Formula	C21H29Cl2N3O4S
Mol. masa	490,44 g/mol
SMILES	eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća	?
Pravni status	Nije kontrolisan
Način primene	Oralno

Reference

1. Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
3. „Science Links Japan | PRX-07034, a Potent and Selective 5-HT6 Receptor Antagonist, Reduces Food Intake and Body Weight in Rats”. Arhivirano iz originala na datum 2012-02-29.
4. Fone KC (November 2008). „An update on the role of the 5-hydroxytryptamine6 receptor in cognitive function”. Neuropharmacology 55 (6): 1015–22. DOI:10.1016/j.neuropharm.2008.06.061. PMID 18655798.
5. „Science Links Japan | Combination of sub-threshold doses of Aricept and PRX-07034, a novel 5-HT6 receptor antagonist, enhances Novel Object Discrimination (NOD) memory”. Arhivirano iz originala na datum 2012-02-29.
6. Halford JC, Harrold JA, Boyland EJ, Lawton CL, Blundell JE (2007). „Serotonergic drugs : effects on appetite expression and use for the treatment of obesity”. Drugs 67 (1): 27–55. PMID 17209663.

Spoljašnje veze

	Portal Medicina
	Portal Hemija

• Preclinical Data on Predix Pharmaceuticals' 5-HT6 Antagonist for Obesity and Cognitive...
• Epix’s Experimental Drug PRX-07034 Shows Potential Benefit on Cognition, Obesity