POLD1

Katalitička podjedinica DNK polimeraze delta je enzim koji je kod ljudi kodiran POLD1 genom.^[1][2] Ona je komponenta kompleksa DNK polimeraza delta.

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Polimeraza (DNK vođena), delta 1, katalitička podjednica
Identifikatori
Simboli	POLD1; CDC2; CRCS10; POLD
Vanjski ID	OMIM: 174761 MGI: 97741 HomoloGene: 2014 GeneCards: POLD1 Gene
EC broj	2.7.7.7
Ontologija gena Molekulska funkcija • nukleotidno vezivanje • DNK vezivanje • hromatinsko vezivanje Ćelijska komponenta • kompleks popravke nukleotidnim isecanjem • nukleus • nukleoplazma Biološki proces • S faza mitotičkog ćelijskog ciklusa • mitotički ćelijski ciklus • telomerno održavanje rekombinacijom
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta	Čovek	Miš
Entrez	5424	18971
Ensembl	ENSG00000062822	ENSMUSG00000038644
UniProt	P28340	P52431
Ref. Sekv. (iRNK)	NM_001256849	NM_011131
Ref. Sekv. (protein)	NP_001243778	NP_035261
Lokacija (UCSC)	Chr 19: 50.89 - 50.92 Mb	Chr 7: 44.53 - 44.55 Mb
PubMed pretraga

POLD1, zajedno sa enzimom POLE, je asocirana sa višestrukim adenomom.^[3]

Reference

1. Chung DW, Zhang JA, Tan CK, Davie EW, So AG, Downey KM (Feb 1992). „Primary structure of the catalytic subunit of human DNA polymerase delta and chromosomal location of the gene”. Proc Natl Acad Sci U S A 88 (24): 11197–201. DOI:10.1073/pnas.88.24.11197. PMC 53101. PMID 1722322.
2. „Entrez Gene: POLD1 polymerase (DNA directed), delta 1, catalytic subunit 125kDa”.
3. Palles C, Cazier JB et al. Nature Genetics 2013. Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas.

Literatura

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• Smith RW, Nasheuer HP (2002). „Control of complex formation of DNA polymerase alpha-primase and cell-free DNA replication by the C-terminal amino acids of the largest subunit p180.”. FEBS Lett. 527 (1-3): 143–6. DOI:10.1016/S0014-5793(02)03197-6. PMID 12220650.
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