Orotat fosforiboziltransferaza

Orotat fosforiboziltransferaza (EC 2.4.2.10, orotidilna kiselina fosforilaza, orotidin-5'-fosfat pirofosforilaza, OPRTaze, orotat fosforibozil pirofosfat transferaza, orotinsko kiselinska fosforiboziltransferaza, orotidin 5'-monofosfatna pirofosforilaza, orotidin monofosfatna pirofosforilaza, orotidinska fosforiboziltransferaza, orotidilatna fosforiboziltransferaza, orotidilatna pirofosforilaza, orotidilno kiselinska pirofosforilaza, orotidilna fosforilaza, orotidilna pirofosforilaza) je enzim sa sistematskim imenom orotidin-5'-fosfat:difosfat fosfo-alfa-D-ribozil-transferaza.^[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju

orotidin 5'-fosfat + difosfat ${\displaystyle \rightleftharpoons }$ orotat + 5-fosfo-alfa-D-riboza 1-difosfat

Orotat fosforiboziltransferaza
Identifikatori
EC broj	2.4.2.10
CAS broj	9030-25-5
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

Enzim iz viših eukariota takođe katalizuje reakcije enzima EC 4.1.1.23, orotidin-5'-fosfat dekarboksilaza.

Reference

1. Jones, M.E., Kavipurapu, P.R. and Traut, T.W. (1978). „Orotate phosphoribosyltransferase: orotidylate decarboxylase (Ehrlich ascites cell)”. Methods Enzymol. 51: 155-167. PMID 692383.
2. Lieberman, I., Kornberg, A. and Simms, E.S. (1955). „Enzymatic synthesis of pyrimidine nucleotides. Orotidine-5′-phosphate and uridine-5′-phosphate”. J. Biol. Chem. 215: 403-415. PMID 14392174.
3. McClard, R.W., Black, M.J., Livingstone, L.R. and Jones, M.E. (1980). „Isolation and initial characterization of the single polypeptide that synthesizes uridine 5′-monophosphate from orotate in Ehrlich ascites carcinoma. Purification by tandem affinity chromatography of uridine-5′-monophosphate synthase”. Biochemistry 19: 4699-4706. PMID 6893554.

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Spoljašnje veze

• MeSH Orotate+phosphoribosyltransferase