Netilmicin

Netilmicin je član aminoglikozidne familije antibiotika. Ti antibiotici imaju sposobnost ubijanja širokog opsega bakterijskih vrsta. Netilmicin se ne apsorbuje iz stomaka te se dozira putem injekcije ili infuzije. On se koristi jedino za tretman ozbiljnih infekcija, posebno onih koje su otporne na gentamicin.

Netilmicin

(IUPAC) ime
(2R,3R,4R,5R)-​2-​{[(1S,2S,3R,4S,6R)-​4-​amino-​3-​{[(2S,3R)-​3-​amino-​6-​(aminometil)-​3,4-​dihidro-2H-​piran-​2-​il]oksi​6-​(etilamino)-​2-​hidroksicikloheksil]oksi​5-​metil-​4-​(metilamino)oksan-​3,5-diol
Klinički podaci
AHFS/Drugs.com	Monografija
MedlinePlus	a605011
Identifikatori
CAS broj	56391-56-1
ATC kod	J01GB07 S01AA23
PubChem[1][2]	41859
DrugBank	DB00955
ChemSpider[3]	38195
UNII	4O5J85GJJB Y
KEGG[4]	D08268 Y
ChEMBL[5]	CHEMBL1572 Y
Hemijski podaci
Formula	C21H41N5O7
Mol. masa	475,58 g/mol
SMILES	eMolekuli & PubHem
Farmakokinetički podaci
Bioraspoloživost	~0%
Poluvreme eliminacije	2,5 sata
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

Refernce

1. Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
4. Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
5. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

Literatura

• Hemsworth S, Nunn A, Selwood K, Osborne C, Jones A, Pizer B (2005). „Once-daily netilmicin for neutropenic pyrexia in paediatric oncology.”. Acta Paediatr 94 (3): 268–74. DOI:10.1080/08035250510025923. PMID 16028643.
• Klingenberg C, Småbrekke L, Lier T, Flaegstad T (2004). „Validation of a simplified netilmicin dosage regimen in infants.”. Scand J Infect Dis 36 (6-7): 474–9. DOI:10.1080/00365540410020613. PMID 15307571.
• Brooks J, Marlow N, Reeves B, Millar M (2004). „Use of once-daily netilmicin to treat infants with suspected sepsis in a neonatal intensive care unit.”. Biol Neonate 86 (3): 170–5. DOI:10.1159/000079423. PMID 15237240.