Metabotropni glutamatni receptor 7

Metabotropni glutamatni receptor 7 je protein koji je kod ljudi kodiran GRM7 genom.^[1][2][3]

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Metabotropni glutamatni receptor 7
PDB prikaz baziran na 2e4z.
Dostupne strukture
3MQ4
Identifikatori
Simboli	GRM7; GLUR7; GPRC1G; MGLU7; MGLUR7
Vanjski ID	OMIM: 604101 MGI: 1351344 HomoloGene: 20233 IUPHAR: mGlu7 GeneCards: GRM7 Gene
Ontologija gena Molekularna funkcija • aktivnost grupe III metabotropnih glutamatnih receptora • aktivnost prenosa signala • receptorska aktivnost • aktivnost G protein spregnutog receptora • aktivnost naponom kontrolisanog kalcijumovog kanala • aktivnost regulatora kalcijumovog kanala • vezivanje jona kalcijuma • aktivnost glutamatnog receptora • aktivnsot inhibitor adenylat ciklaze • glutamatno vezivanje • vezivanje PDZ domena • serinsko vezivanje Celularna komponenta • ćelijska membrana • integralno sa ćelijskom membranom • ćelijski korteks • integralno sa membranom • akson • dendrit • asimetrična sinapsa • presinaptička membrana • dendritna osovina • postsinaptička membrana • presinaptička aktivna zona Biološki proces • uslovna averzija ukusa • respons na strah • negativna regulacija aktivnosti adenilat ciklaze • sinaptička transmisija • senzorna percepcija zvuka • senzorna percepcija mirisa • kratkotrajna memorija • negativna regulacija glutamatne sekrecije • ponašanje odraslih • negativna regulacija cAMP biosinthetčkog procesa
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta	Čovek	Miš
Entrez	2917	108073
Ensembl	ENSG00000196277	ENSMUSG00000056755
UniProt	Q14831	Q68ED2
RefSeq (mRNA)	NM_000844.3	NM_177328.3
RefSeq (protein)	NP_000835.1	NP_796302.2
Lokacija (UCSC)	Chr 3: 6.81 - 7.78 Mb	Chr 6: 110.6 - 111.52 Mb
PubMed pretraga

Funkcija

L-glutamat je jedan od glavnih ekscitatornih neurotransmitera u centralnom nervnom sistemu. On aktivira jonotropne i metabotropne glutamatne receptore. Glutamatergična neurotransmisija učestvuje u većini aspekata normalih moždanih funkcija i njena perturbacija se javlja kod mnogih neuropatoloških oboljenja. Metabotropni glutamatni receptori su familija G protein spregnutih receptora, koja se deli u tri grupe na osnovu homologije sekvenci, mehanizama prenosa signala, i farmakoloških svojstava. Grupa I obuhvata GRM1 i GRM5. Ti receptori aktiviraju fosfolipazu C. Grupa II obuhvata GRM2 i GRM3, dok grupa III obuhvata GRM4, GRM6, GRM7 i GRM8. Receptori grupe II i III su povezani inhibicijom kaskade cikličnog AMP-a ali se razlikuju u njihovim selektivnostima za agoniste.^[3]

Ligandi

Agonisti

• AMN082: alosterni agonist;^[4][5] indukuje brzu internalizaciju;^[6] non-glutamatergic binding component^[5]

Antagonisti

• MMPIP: alosterni antagonist/inverzni agonist^[7]

Interakcije

Metabotropni glutamatni receptor 7 formira interakcije sa PICK1.^[8]

Reference

1. Okamoto N, Hori S, Akazawa C, Hayashi Y, Shigemoto R, Mizuno N, Nakanishi S (February 1994). „Molecular characterization of a new metabotropic glutamate receptor mGluR7 coupled to inhibitory cyclic AMP signal transduction”. J Biol Chem 269 (2): 1231–6. PMID 8288585.
2. Makoff A, Pilling C, Harrington K, Emson P (January 1997). „Human metabotropic glutamate receptor type 7: molecular cloning and mRNA distribution in the CNS”. Brain Res Mol Brain Res 40 (1): 165–70. DOI:10.1016/0169-328X(96)00110-6. PMID 8840028.
3. „Entrez Gene: GRM7 glutamate receptor, metabotropic 7”.
4. Li X, Gardner EL, Xi ZX (2008). „The Metabotropic Glutamate Receptor 7 (mGluR7) Allosteric Agonist AMN082 Modulates Nucleus Accumbens GABA and Glutamate, but not Dopamine, in Rats”. Neuropharmacology 54 (3): 542–51. DOI:10.1016/j.neuropharm.2007.11.005. PMC 2410088. PMID 18155073.
5. Palucha A, Klak K, Branski P, van der Putten H, Flor PJ, Pilc A (2007). „Activation of the mGlu7 receptor elicits antidepressant-like effects in mice”. Psychopharmacology (Berl.) 194 (4): 555–62. DOI:10.1007/s00213-007-0856-2. PMID 17622518.
6. Pelkey KA, Yuan X, Lavezzari G, Roche KW, McBain CJ (2007). „mGluR7 undergoes rapid internalization in response to activation by the allosteric agonist AMN082”. Neuropharmacology 52 (1): 108–17. DOI:10.1016/j.neuropharm.2006.07.020. PMID 16914173.
7. Suzuki G, Tsukamoto N, Fushiki H et al. (2007). „In vitro pharmacological characterization of novel isoxazolopyridone derivatives as allosteric metabotropic glutamate receptor 7 antagonists”. J. Pharmacol. Exp. Ther. 323 (1): 147–56. DOI:10.1124/jpet.107.124701. PMID 17609420.
8. Dev, K K; Nakajima Y, Kitano J, Braithwaite S P, Henley J M, Nakanishi S (October 2000). „PICK1 interacts with and regulates PKC phosphorylation of mGLUR7”. J. Neurosci. (UNITED STATES) 20 (19): 7252–7. PMID 11007882.

Literatura

• Scherer SW, Duvoisin RM, Kuhn R i dr.. (1997). „Localization of two metabotropic glutamate receptor genes, GRM3 and GRM8, to human chromosome 7q”. Genomics 31 (2): 230–3. DOI:10.1006/geno.1996.0036. PMID 8824806.
• Flor PJ, Van Der Putten H, Rüegg D i dr.. (1997). „A novel splice variant of a metabotropic glutamate receptor, human mGluR7b”. Neuropharmacology 36 (2): 153–9. DOI:10.1016/S0028-3908(96)00176-1. PMID 9144652.
• Wu S, Wright RA, Rockey PK i dr.. (1998). „Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells”. Brain Res. Mol. Brain Res. 53 (1–2): 88–97. DOI:10.1016/S0169-328X(97)00277-5. PMID 9473604.
• Nakajima Y, Yamamoto T, Nakayama T, Nakanishi S (1999). „A relationship between protein kinase C phosphorylation and calmodulin binding to the metabotropic glutamate receptor subtype 7”. J. Biol. Chem. 274 (39): 27573–7. DOI:10.1074/jbc.274.39.27573. PMID 10488094.
• O'Connor V, El Far O, Bofill-Cardona E i dr.. (1999). „Calmodulin dependence of presynaptic metabotropic glutamate receptor signaling”. Science 286 (5442): 1180–4. DOI:10.1126/science.286.5442.1180. PMID 10550060.
• Barbon A, Ferraboli S, Barlati S (2000). „Assignment of the human metabotropic glutamate receptor gene GRM7 to chromosome 3p26.1→p25.2 by radiation hybrid mapping”. Cytogenet. Cell Genet. 88 (3–4): 288. DOI:10.1159/000015541. PMID 10828612.
• Dev KK, Nakajima Y, Kitano J i dr.. (2001). „PICK1 interacts with and regulates PKC phosphorylation of mGLUR7”. J. Neurosci. 20 (19): 7252–7. PMID 11007882.
• Bolonna AA, Kerwin RW, Munro J i dr.. (2001). „Polymorphisms in the genes for mGluR types 7 and 8: association studies with schizophrenia”. Schizophr. Res. 47 (1): 99–103. DOI:10.1016/S0920-9964(99)00235-2. PMID 11163549.
• Hirbec H, Perestenko O, Nishimune A i dr.. (2002). „The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs”. J. Biol. Chem. 277 (18): 15221–4. DOI:10.1074/jbc.C200112200. PMID 11891216.
• Enz R (2002). „The actin-binding protein Filamin-A interacts with the metabotropic glutamate receptor type 7”. FEBS Lett. 514 (2–3): 184–8. DOI:10.1016/S0014-5793(02)02361-X. PMID 11943148.
• Saugstad JA, Yang S, Pohl J i dr.. (2002). „Interaction between metabotropic glutamate receptor 7 and alpha tubulin”. J. Neurochem. 80 (6): 980–8. DOI:10.1046/j.0022-3042.2002.00778.x. PMC 2925652. PMID 11953448.
• Schulz HL, Stohr H, Weber BH (2002). „Characterization of three novel isoforms of the metabotrobic glutamate receptor 7 (GRM7)”. Neurosci. Lett. 326 (1): 37–40. DOI:10.1016/S0304-3940(02)00306-3. PMID 12052533.
• Ota T, Suzuki Y, Nishikawa T i dr.. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039.
• Kobayashi Y, Akiyoshi J, Kanehisa M i dr.. (2007). „Lack of polymorphism in genes encoding mGluR 7, mGluR 8, GABA(A) receptor alfa-6 subunit and nociceptin/orphanin FQ receptor and panic disorder”. Psychiatr. Genet. 17 (1): 9. DOI:10.1097/YPG.0b013e32801118bc. PMID 17167337.

Vanjske veze

• „Metabotropic Glutamate Receptors: mGlu₇”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2016-03-03.