Mesulergin

Mesulergin
(IUPAC) ime
	N'-[(8α)-1,6-dimethylergolin-8-yl)-N,N-dimethylsulfamide
Klinički podaci
Identifikatori
CAS broj	64795-35-3
ATC kod	?
PubChem	68848
ChemSpider	62081
UNII	SML95FK06I
Hemijski podaci
Formula	C18H26N4O2S
Mol. masa	362.49 g/mol
SMILES	eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

Mesulergin je psihoaktivni lek iz ergolinske hemijske klase koji deluje kao ligand na raznim serotoninskim i dopaminskim receptorima.^[4]^[5]

Kratke činjenice (IUPAC) ime, Klinički podaci ...

Zatvori

Ovo jedinjenje je bilo u kliničkim ispitivanjima za tretman Parkinsonove bolesti, međutim dalji razvoj je zaustavljen usled nepoželjnih histoloških abnormalnosti ustanovljenih u ispitivanjima na pacovima.^[6]

Metergolin

[1]
Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
[2]
Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
[3]
Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
[4]
Closse A (May 1983). „[³H]-Mesulergine, a selective ligand for serotonin-2 receptors”. Life Sci. 32 (21): 2485–95. DOI:10.1016/0024-3205(83)90375-2. PMID 6855451.
[5]
Markstein R (November 1983). „Mesulergine and its 1,20-N,N-bidemethylated metabolite interact directly with D1- and D2-receptors”. Eur. J. Pharmacol. 95 (1-2): 101–7. DOI:10.1016/0014-2999(83)90272-8. PMID 6230246.
[6]
Dupont E, Mikkelsen B, Jakobsen J (April 1986). „Mesulergine in early Parkinson's disease: a double blind controlled trial”. J. Neurol. Neurosurg. Psychiatr. 49 (4): 390–5. DOI:10.1136/jnnp.49.4.390. PMC 1028763. PMID 3517235.

	Portal Medicina
	Portal Hemija

MeSH Mesulergine

[1] [1]
Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] [2]
Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] [3]
Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[pmid6855451-4] [4]
Closse A (May 1983). „[³H]-Mesulergine, a selective ligand for serotonin-2 receptors”. Life Sci. 32 (21): 2485–95. DOI:10.1016/0024-3205(83)90375-2. PMID 6855451.

[pmid6230246-5] [5]
Markstein R (November 1983). „Mesulergine and its 1,20-N,N-bidemethylated metabolite interact directly with D1- and D2-receptors”. Eur. J. Pharmacol. 95 (1-2): 101–7. DOI:10.1016/0014-2999(83)90272-8. PMID 6230246.

[pmid3517235-6] [6]
Dupont E, Mikkelsen B, Jakobsen J (April 1986). „Mesulergine in early Parkinson's disease: a double blind controlled trial”. J. Neurol. Neurosurg. Psychiatr. 49 (4): 390–5. DOI:10.1136/jnnp.49.4.390. PMC 1028763. PMID 3517235.

[4]

[5]

[1]

[2]

[3]

[6]

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Mesulergin

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Literatura

Spoljašnje veze

(IUPAC) ime

N'-[(8α)-1,6-dimethylergolin-8-yl)-N,N-dimethylsulfamide
Klinički podaci
Identifikatori
CAS broj	64795-35-3
ATC kod	?
PubChem^[1]^[2]	68848
ChemSpider^[3]	62081
UNII	SML95FK06I^Y
Hemijski podaci
Formula	C₁₈H₂₆N₄O₂S
Mol. masa	362.49 g/mol
SMILES	eMolekuli & PubHem

Farmakoinformacioni podaci
Trudnoća	?
Pravni status