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Melanokortini su grupa peptidnih hormona u koje se ubrajaju adrenokortikotropski hormon (ACTH) i razne forme melanocit-stimulišućeg hormona (MSH).[1] Oni mogu biti sintetički (kreirani u laboratoriji) ili endogeno proizvedeni iz proopiomelanokortina (POMC) u pituitarnoj žlezdi.[2] Melanokortini dejstvuju putem vezivanja za i aktiviranja melanokortinskog receptora.
Derivati pro-opiomelanokortina | |||||||||
---|---|---|---|---|---|---|---|---|---|
POMC | |||||||||
γ-MSH | ACTH | β-lipotropin | |||||||
α-MSH | CLIP | γ-lipotropin | β-endorfin | ||||||
β-MSH |
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