LP-44

LP-44 je lek koji deluje kao potentan i selektivan agonist na 5HT₇ serotoninskom receptoru. Mada je LP-44 manje selektivan od srodnog jedinjenja LP-12, on je bio u široj upotrebi u istraživanjima i korišten da se odredi kompleksna uloga 5-HT₇ receptora u nekoliko aspekata moždane funkcije, uključujući regulaciju cirkadijanskog ciklusa i ulogu u stresu, učenju i memoriji.^[3][4][5][6]

LP-44

(IUPAC) ime
4-[2-(metiltio)fenil]-N-(1,2,3,4-tetrahidronaftalen-1-il)-1-piperazineheksanamid
Klinički podaci
Identifikatori
CAS broj	824958-12-5
ATC kod	nije dodeljen
PubChem[1][2]	11224758
Hemijski podaci
Formula	C27H37N3OS
Mol. masa	451,666 g/mol
SMILES	eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

Reference

1. Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
3. Monti JM, Leopoldo M, Jantos H (August 2008). „The serotonin 5-HT7 receptor agonist LP-44 microinjected into the dorsal raphe nucleus suppresses REM sleep in the rat”. Behavioural Brain Research 191 (2): 184–9. DOI:10.1016/j.bbr.2008.03.025. PMID 18466985.
4. Xu Y, Zhang C, Wang R, Govindarajan SS, Barish PA, Vernon MM, Fu C, Acharya AP, Chen L, Boykin E, Yu J, Pan J, O'Donnell JM, Ogle WO (May 2011). „Corticosterone induced morphological changes of hippocampal and amygdaloid cell lines are dependent on 5-HT7 receptor related signal pathway”. Neuroscience 182: 71–81. DOI:10.1016/j.neuroscience.2011.02.042. PMID 21371532.
5. Monti JM (August 2011). „Serotonin control of sleep-wake behavior”. Sleep Medicine Reviews 15 (4): 269–81. DOI:10.1016/j.smrv.2010.11.003. PMID 21459634.
6. Costa L, Trovato C, Musumeci SA, Catania MV, Ciranna L (April 2011). „5-HT(1A) and 5-HT(7) receptors differently modulate AMPA receptor-mediated hippocampal synaptic transmission”. Hippocampus 22 (4): 790–801. DOI:10.1002/hipo.20940. PMID 21538661.

Povezano

• AS-19
• E-55888
• LP-211

Spoljašnje veze

	Portal Medicina
	Portal Hemija