Komponenta komplementa 3 (C3) je protein imunskog sistema. On ima centralnu ulogu u sistemu komplementa i doprinosi urođenoj imunosti. Kod ljudi je on kodiran na hromozomu 19 C3 genom.[1][2]
Kratke činjenice Dostupne strukture, Identifikatori ...
Komponenta komplementa 3 |
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PDB prikaz baziran na 1c3d. |
Dostupne strukture |
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1c3d, 1ghq, 1w2s, 2a73, 2a74, 2b39, 2gox, 2hr0, 2i07, 2ice, 2icf |
Identifikatori |
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Simboli | C3; ASP; CPAMD1 |
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Vanjski ID | OMIM: 120700 MGI: 88227 HomoloGene: 68031 GeneCards: C3 Gene |
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Ortolozi |
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Vrsta | Čovek | Miš | |
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Entrez | 718 | 12266 | |
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Ensembl | ENSG00000125730 | ENSMUSG00000024164 | |
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UniProt | P01024 | Q207D2 | |
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RefSeq (mRNA) | NM_000064 | NM_009778 | |
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RefSeq (protein) | NP_000055 | NP_033908 | |
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Lokacija (UCSC) | Chr 19: 6.68 - 6.73 Mb | Chr 17: 56.89 - 56.91 Mb | |
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PubMed pretraga | | | |
Zatvori
C3 ima centralnu mesto u aktivaciji sistema komplementa.[3] Njegova aktivacija je neophodna u putevima aktivacije klasičnog i alternativnnog komplementa. Ljudi sa C3 deficijencijom su podložni bakterijskim infekcijama.[4][5]
Nekoliko C3 kristalnih struktura je rešeno.[6] Ovaj protein se sastoji od 13 domena.[7][8][9][10]
Za komponenta komplementa 3 je pokazano da interaguje sa faktorom H.[11][12]
Matsuyama W, Nakagawa M, Takashima H, Muranaga F, Sano Y, Osame M (December 2001). „Molecular analysis of hereditary deficiency of the third component of complement (C3) in two sisters”. Intern. Med. 40 (12): 1254–8. DOI:10.2169/internalmedicine.40.1254. PMID 11813855. Janssen BJ, Huizinga EG, Raaijmakers HC, Roos A, Daha MR, Nilsson-Ekdahl K, Nilsson B, Gros P (September 2005). „Structures of complement component C3 provide insights into the function and evolution of immunity”. Nature 437 (7058): 505–11. DOI:10.1038/nature04005. PMID 16177781. Janssen BJ, Christodoulidou A, McCarthy A, Lambris JD, Gros P (November 2006). „Structure of C3b reveals conformational changes that underlie complement activity”. Nature 444 (7116): 213–6. DOI:10.1038/nature05172. PMID 17051160. Wiesmann C, Katschke KJ, Yin J, Helmy KY, Steffek M, Fairbrother WJ, McCallum SA, Embuscado L, DeForge L, Hass PE, van Lookeren Campagne M (November 2006). „Structure of C3b in complex with CRIg gives insights into regulation of complement activation”. Nature 444 (7116): 217–20. DOI:10.1038/nature05263. PMID 17051150. Fredslund F, Jenner L, Husted LB, Nyborg J, Andersen GR, Sottrup-Jensen L (August 2006). „The structure of bovine complement component 3 reveals the basis for thioester function”. J. Mol. Biol. 361 (1): 115–27. DOI:10.1016/j.jmb.2006.06.009. PMID 16831446. Jokiranta, T S; Westin J, Nilsson U R, Nilsson B, Hellwage J, Löfås S, Gordon D L, Ekdahl K N, Meri S (March 2001). „Complement C3b interactions studied with surface plasmon resonance technique”. Int. Immunopharmacol. (Netherlands) 1 (3): 495–506. DOI:10.1016/S1567-5769(00)00042-4. ISSN 1567-5769. PMID 11367533.
- Bradley, D T; Zipfel, P F; Hughes, A E (2011). „Complement in age-related macular degeneration: a focus on function”. Eye. DOI:10.1038/eye.2011.37.