Klobenpropit

Klobenpropit
(IUPAC) ime
	N'-[(4-hlorofenil)metil]-1-[3-(3H-imidazol-4-il)propilsulfanil]formamidin
Klinički podaci
Identifikatori
CAS broj	145231-45-4
ATC kod	nije dodeljen
PubChem	2790
ChemSpider	2688
ChEMBL	CHEMBL14690
Hemijski podaci
Formula	C14H17ClN4S
Mol. masa	308,83 g/mol
SMILES	eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

Klobenpropit je histaminski antagonist H₃ receptora.^[5] On ima neuroprotektivno dejstvo, koje ostvaruje putem stimulacije otpuštanja gama-aminobuterne kiseline u mozgu.^[6]

Kratke činjenice (IUPAC) ime, Klinički podaci ...

Zatvori

[1]
Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
[2]
Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
[3]
Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
[4]
Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
[5]
Sahlholm K, Nilsson J, Marcellino D, Fuxe K, Arhem P (2007). „The human histamine H3 receptor couples to GIRK channels in Xenopus oocytes”. Eur. J. Pharmacol. 567 (3): 206–10. DOI:10.1016/j.ejphar.2007.04.032. PMID 17537431.
[6]
Dai H, Fu Q, Shen Y, Hu W, Zhang Z, Timmerman H, Leurs R, Chen Z. The histamine H3 receptor antagonist clobenpropit enhances GABA release to protect against NMDA-induced excitotoxicity through the cAMP/protein kinase A pathway in cultured cortical neurons. European Journal of Pharmacology. 2007 Jun 1;563(1-3):117-23. PMID 17350613

Antagonist H₃ receptora

	Portal Medicina
	Portal Hemija

[1] [1]
Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit

[2] [2]
Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.

[3] [3]
Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit

[4] [4]
Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit

[pmid17537431-5] [5]
Sahlholm K, Nilsson J, Marcellino D, Fuxe K, Arhem P (2007). „The human histamine H3 receptor couples to GIRK channels in Xenopus oocytes”. Eur. J. Pharmacol. 567 (3): 206–10. DOI:10.1016/j.ejphar.2007.04.032. PMID 17537431.

[6] [6]
Dai H, Fu Q, Shen Y, Hu W, Zhang Z, Timmerman H, Leurs R, Chen Z. The histamine H3 receptor antagonist clobenpropit enhances GABA release to protect against NMDA-induced excitotoxicity through the cAMP/protein kinase A pathway in cultured cortical neurons. European Journal of Pharmacology. 2007 Jun 1;563(1-3):117-23. PMID 17350613

[5]

[6]

[1]

[2]

[3]

[4]

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Klobenpropit

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Reference

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Spoljašnje veze

(IUPAC) ime

N'-[(4-hlorofenil)metil]-1-[3-(3H-imidazol-4-il)propilsulfanil]formamidin
Klinički podaci
Identifikatori
CAS broj	145231-45-4
ATC kod	nije dodeljen
PubChem^[1]^[2]	2790
ChemSpider^[3]	2688
ChEMBL^[4]	CHEMBL14690
Hemijski podaci
Formula	C₁₄H₁₇Cl N₄S
Mol. masa	308,83 g/mol
SMILES	eMolekuli & PubHem

Farmakoinformacioni podaci
Trudnoća	?
Pravni status