Katehol O-metiltransferaza

Katehol O-metiltransferaza (EC 2.1.1.6, COMT I, COMT II, S-COMT, rastvorna forma katehol-O-metiltransferaze, MB-COMT, membranska forma katehol-O-metiltransferaze, kateholna metiltransferaza, kateholaminska O-metiltransferaza) je enzim sa sistematskim imenom S-adenozil-L-metionin:katehol O-metiltransferaza.^[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju

S-adenozil-L-metionin + katehol ${\displaystyle \rightleftharpoons }$ S-adenozil-L-homocistein + gvajakol

Katehol O-metiltransferaza
Identifikatori
EC broj	2.1.1.6
CAS broj	9012-25-3
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

Enzim sisara deluje brže na kateholamine kao što je adrenalin ili noradrenalin nego na katehole.

Reference

1. Axelrod, J. and Tomchick, R. (1958). „Enzymatic O-methylation of epinephrine and other catechols”. J. Biol. Chem. 233: 702-705. PMID 13575440.
2. Gulliver, P.A. and Tipton, K.F. (1979). „The purification and properties of pig brain catechol-O-methyltransferase”. J. Neurochem. 32: 1525-1529. PMID 438821.
3. Huh, M.M.O. and Friedhof, A.J. (1979). „Multiple molecular forms of catechol-O-methyltransferase. Evidence for two distinct forms, and their purification and physical characterization”. J. Biol. Chem. 254: 299-308. PMID 762061.

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Spoljašnje veze

• MeSH Catechol+O-methyltransferase