Fosfomevalonat kinaza

Fosfomevalonat kinaza (EC 2.7.4.2, ATP:5-fosfomevalonatna fosfotransferaza, 5-fosfomevalonatna kinaza, mevalonat fosfatna kinaza, mevalonat-5-fosfatna kinaza, mevalonsko kiselinska fosfatna kinaza) je enzim sa sistematskim imenom ATP:(R)-5-fosfomevalonat fosfotransferaza.^[1][2][3] Ovaj enzim katalizuje sledeću hemijsku reakciju

ATP + (R)-5-fosfomevalonat ${\displaystyle \rightleftharpoons }$ ADP + (R)-5-difosfomevalonat

Fosfomevalonat kinaza
Identifikatori
EC broj	2.7.4.2
CAS broj	9026-46-4
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

Reference

1. Bloch, K., Chaykin, S., Phillips, A.H. and de Waard, A. (1959). „Mevalonic acid pyrophosphate and isopentenyl pyrophosphate”. J. Biol. Chem. 234: 2595-2604. PMID 13801508.
2. Henning, U., Möslein, E.M. and Lynen, F. (1959). „Biosynthesis of terpenes. V. Formation of 5-pyrophosphomevalonic acid by phosphomevalonic kinase”. Arch. Biochem. Biophys. 83: 259-267. PMID 13662013.
3. Levy, G.B. and Popják, G. (1960). „Studies on the biosynthesis of cholesterol. 10. Mevalonic kinase from liver”. Biochem. J. 75: 417-428. PMID 14416398.

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Spoljašnje veze

• MeSH Phosphomevalonate+kinase