Fenformin

Phenformin je antidijabetesni lek iz biguanidne klase. On je bio u prodaji, ali je povučen sa tržišta tokom 1970-tih zbog povišenog rizika od laktacidoze, koja je fatalna u 50% slučajeva.

Fenformin

(IUPAC) ime
2-(N-fenetilkarbamimidoil)guanidin
Klinički podaci
AHFS/Drugs.com	Internacionalno ime leka
Identifikatori
CAS broj	114-86-3
ATC kod	A10BA01
PubChem[1][2]	8249
DrugBank	DB00914
ChemSpider[3]	7953
UNII	DD5K7529CE Y
KEGG[4]	D08351 Y
ChEBI	CHEBI:8064 Y
ChEMBL[5]	CHEMBL170988 Y
Hemijski podaci
Formula	C10H15N5
Mol. masa	205,26 g/mol
SMILES	eMolekuli & PubHem
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

Phenformin je otkriven 1957. Klinička ispitivanja su počela 1958. i ustanovljeno je da je efektivan, ali da uzrokuje gastrointestinalne nuspojave.^[6]

Reference

1. Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
2. Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
3. Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
4. Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
5. Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
6. McKendry JB, Kuwayti K, Rado PP (May 1959). „Clinical Experience with DBI (Phenformin) in the Management of Diabetes”. Can Med Assoc J 80 (10): 773–8. PMC 1831029. PMID 13652024.

Spoljašnje veze

	Portal Medicina
	Portal Hemija