Dejodinaza

Dejodinaza (jodid peroksidaza, monodejodinaza) je peroksidazni enzim koji učestvuje u aktivaciji ili deaktivaciji tiroidnih hormona. Generalno, T4 (tiroksin) se konvertuje u T3 (trijodotironin) posredstvom enzima dejodinaze u ciljnim ćelijama.^[1]

Tiroksin 5'-dejodinaza
Identifikatori
EC broj	1.97.1.10
CAS broj	70712-46-8
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Ontologija gena	AmiGO / EGO
Pretraga PMC articles PubMed articles NCBI Protein search

Tipovi dejodinaza su:

familija	prostetička grupa	geni
Jodotironin dejodinaza[2]	selenijum	DIO1, DIO2, DIO3
Jodotirozin dejodinaza	flavin	IYD

Pri gladovanju, dejodinaza je inhibirana i time se snižava nivo metabolizma. Međutim, u mozgu to noje slučaj.

Reference

1. Donald Voet, Judith G. Voet (2005). Biochemistry (3 izd.). Wiley. ISBN 978-0-471-19350-0.
2. Dietrich Behne, Antonios Kyriakopoulos, Harald Meinhold, Josef Köhrle (1990-12-30). „Identification of type I iodothyronine 5′-deiodinase as a selenoenzyme”. Biochemical and Biophysical Research Communications 173 (3): 1143–1149.

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Spoljašnje veze

• MeSH Deiodinase