2-Metil-6-(feniletinil)piridin (MPEP) je lek koji se koristi u naučnim istraživanjima. On je bio jedan od prvih selektivnih antagonista metabotropnog glutamatnog receptora mGluR5. Ovo jedinjenje je razvila farmaceutska kompanija Novartis krajem 1990-tih.[4] On proizvodi neuroprotektivne efekte nakon akutne moždane povrede u životinjskim ispitivanjima, mada nije jasno da li su ti rezultati direktna posledica mGluR5 blokade, jer on deluje i kao slab NMDA antagonist,[5][6] i kao pozitivni alosterni modulator mGlu4 receptora,[7] a isto tako postoje dokazi o funkcionalnim interakcijama između mGluR5 i NMDA receptora u pojedinim populacijama neurona.[8] Takođe je pokazano da proizvodi antidepresivne[9][10][11] i anksiolitičke efekte kod životinja,[12][13][14] i da umanjuje dejstvo morfinskog povlačenja,[15] najverovatnije usled direktne interakcije između mGluR5 i μ-opioidnog receptora.[16]
Kratke činjenice (IUPAC) ime, Klinički podaci ...
Zatvori
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