Trombin

Trombin (EC 3.4.21.5, trombaza, trombofort, topikal, trombin-C, tropostazin, aktivatirani krvno-koagulacioni faktor II, krvno-koagulacioni faktor IIa, faktor IIa, E trombin, beta-trombin, gama-trombin) je enzim.^{[1][2][3][4][5][6][7][8]} Ovaj enzim katalizuje sledeću hemijsku reakciju

Selektivno razlaganje Arg-Gly veza u fibrinogenu čime se formira fibrin i odvajaju fibrinopeptidi A i B

Trombin
Identifikatori
EC broj	3.4.21.5
CAS broj	2594047
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB	RCSB PDB PDBe PDBj PDBsum
Pretraga PMC articles PubMed articles NCBI Protein search

Ovaj enzim se formira iz protrombina.

Reference

1. Baughman, D.J. (1970). „Thrombin assay”. Methods Enzymol. 19: 145-157.
2. Magnusson, S. (1970). „Bovine prothrombin and thrombin”. Methods Enzymol. 19: 157-184.
3. Miller, K.D. (1970). „Horse prothrombin”. Methods Enzymol. 19: 140-145.
4. Lundblad, R.L., Kingdon, H.S. and Mann, K.G. (1976). „Thrombin”. Methods Enzymol. 45: 156-176. PMID 1011989.
5. Mann, K.G. (1976). „Prothrombin”. Methods Enzymol. 45: 123-156. PMID 1011988.
6. Davie, E.W., Fujikawa, K., Kurachi, K. and Kisiel, W. (1979). „The role of serine proteases in the blood coagulation cascade”. Adv. Enzymol. 48: 277-318. PMID 367103.
7. Cho, K., Tanaka, T., Cook, R.R., Kisiel, W., Fujikawa, K., Kurachi, K. and Powers, J.C. (1984). „Active-site mapping of bovine and human blood coagulation serine proteases using synthetic peptide 4-nitroanilide and thio ester substrates”. Biochemistry 23: 644-650. PMID 6370301.
8. MacGillivray, R.T.A. and Davie, E.W. (1984). „Characterization of bovine prothrombin mRNA and its translation product”. Biochemistry 23: 1626-1634. PMID 6326805.

Literatura

• Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
• Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
• Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
• Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
• Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
• Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.

Spoljašnje veze

• MeSH Thrombin